Melanie A. Holden, Keele University
Danielle L. Burke, Keele University
Jos Runhaar, Erasmus University Medical Center Rotterdam
Danielle van Der Windt, Keele University
Richard D. Riley, Keele University
Krysia Dziedzic, Keele University
Amardeep Legha, Keele University
Amy L. Evans, Keele University
J Haxby Abbott, University of Otago
Kristin Baker, Boston University
Jenny Brown, Keele University
Kim L. Bennell, University of Melbourne
Daniël Bossen, University of Amsterdam
Lucie Brosseau, University of Ottawa
Kanda Chaipinyo, Srinakharinwirot University
Robin Christensen, Frederiksberg and Bispebjerg Hospital, Copenhagen
Tom Cochrane, University of Canberra
Mariette de Rooij, Amsterdam Rehabilitation Research Centre
Michael Doherty, University of Nottingham
Helen P. French, Royal College of Surgeons in IrelandFollow
Sheila Hickson, Keele University
Rana S. Hinman, University of Melbourne
Marijke Hopman-Rock, University Medical Center, Amsterdam
Michael V. Hurley, St. George's University of London
Carol Ingram, Keele University
Jesper Knoop, Amsterdam Rehabilitation Research Centre
Inga Krauss, University Hospital of Tübingen
Chris McCarthy, Manchester Metropolitan University
Stephen P. Messier, Wake Forest University
Donald L. Patrick, Balikesir University
Nilay Sahin, Balikesir University
Laura A. Talbot, University of Tennessee Health Science Center
Robert Taylor, Keele University
Carolien H. Teirlinck, Erasmus University Medical Center Rotterdam
Marienke van Middelkoop, Erasmus University Medical Center Rotterdam
Christine Walker, Keele University
Nadine E. Foster, Keele University
OA Trial Bank

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Exercise Therapy, Humans, Osteoarthritis, Hip, Osteoarthritis, Knee, Pain, Pain Management, Pain Measurement, Randomized Controlled Trials as Topic, Research Design, Systematic Reviews as Topic


Chartered Society of Physiotherapy Charitable Trust (grant no PRF/16/A07). National Institute for Health Research (NIHR) School of Primary Care Research (grant no 531). National Institute for Health Research (NIHR) School of Primary Care Research Fellowship. NIHR Schoolof Primary Care Research Fellowship. Dutch Arthritis Foundation for their center of excellence ‘osteoarthritis in primary care’. Australian National Health and Medical Research Council Fellowship (no 1058440). Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital. Oak Foundation (OCAY-13-309). PROGRESS Medical Research Council Prognosis Research Strategy (PROGRESS) Partnership (G0902393/99558). Knowledge Mobilisation Research Fellowship (KMRF-2014-03-002) from the NIHR and the NIHR Collaborations for Leadership in Applied Health Research and Care West Midlands. Australian Research Council Future Fellowship (FT130100175). NIHR Research Professorship (NIHRRP-011-015).


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INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise interventions.

METHODS AND ANALYSIS: Systematic review and individual participant data meta-analyses. A previous comprehensive systematic review will be updated to identify randomised controlled trials that compare the effects of therapeutic exercise for people with knee and hip OA on pain and physical function to a non-exercise control. Lead authors of eligible trials will be invited to share individual participant data. Trial-level and participant-level characteristics (for baseline variables and outcomes) of included studies will be summarised. Meta-analyses will use a two-stage approach, where effect estimates are obtained for each trial and then synthesised using a random effects model (to account for heterogeneity). All analyses will be on an intention-to-treat principle and all summary meta-analysis estimates will be reported as standardised mean differences with 95% CI.

ETHICS AND DISSEMINATION: Research ethical or governance approval is exempt as no new data are being collected and no identifiable participant information will be shared. Findings will be disseminated via national and international conferences, publication in peer-reviewed journals and summaries posted on websites accessed by the public and clinicians.



Medicine and Health Sciences | Rehabilitation and Therapy


Holden MA, Burke DL, Runhaar J, van Der Windt D, Riley RD, Dziedzic K, Legha A, Evans AL, Abbott JH, Baker K, Brown J, Bennell KL, Bossen D, Brosseau L, Chaipinyo K, Christensen R, Cochrane T, de Rooij M, Doherty M, French HP, Hickson S, Hinman RS, Hopman-Rock M, Hurley MV, Ingram C, Knoop J, Krauss I, McCarthy C, Messier SP, Patrick DL, Sahin N, Talbot LA, Taylor R, Teirlinck CH, van Middelkoop M, Walker C, Foster NE; OA Trial Bank. BMJ Open. 2017;7(12):e018971.

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This work is licensed under a Creative Commons Attribution 4.0 License.