Peer Reviewed

1

Document Type

Article

Publication Date

30-5-2017

Keywords

Adolescent, Adrenergic alpha-2 Receptor Agonists, Analgesics, Opioid, Anxiety, Child, Child, Preschool, Clonidine, Dexmedetomidine, Humans, Infant, Intensive Care Units, Pediatric, Patient Comfort, Research Design, Respiration, Artificial, Retrospective Studies, Time Factors

Comments

The original article is available at bmjopen.bmj.com

Abstract

INTRODUCTION: Mechanically ventilated children in paediatric intensive care units are commonly administered analgesics and sedative agents to minimise pain and distress and facilitate cooperation with medical interventions. Opioids and benzodiazepines are the most common analgesic and sedative agents but have safety concerns. The α

METHODS AND ANALYSIS: We will conduct a retrospective cohort study in two Irish paediatric intensive care units using clinical information on patient characteristics, sedation scores and drug use. Eligible children admitted between January 2014 and June 2016 who were mechanically ventilated and received an opioid infusion will be included. Patients will be categorised into two exposure categories (received an α

ETHICS AND DISSEMINATION: The study has been approved by the ethics committees of both hospitals. Dissemination will occur via local, national and international presentations for academic and healthcare audiences as well as through peer reviewed publications.

Disciplines

Pharmacy and Pharmaceutical Sciences

Citation

Hayden JC, Dawkins I, Breatnach C, Leacy FP, Foxton J, Healy M, Cousins G, Gallagher PJ, Doherty DR. Effectiveness of α2agonists for sedation in paediatric critical care: study protocol for a retrospective cohort observational study. BMJ Open. 2017;7(5):e013858.

PubMed ID

28566361

DOI Link

10.1136/bmjopen-2016-013858

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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