Peer Reviewed

1

Document Type

Article

Publication Date

17-10-2019

Keywords

cognitive impairment, medication adherence, stroke, cerebrovascular diseases, secondary prevention, caregivers

Funder/Sponsor

Health Research Board [grant numbers SPHeRE2013/1, 1404/7400. RL-15-1579. Irish Heart Foundation [grant number 1296829]

Comments

The original article is available at journals.plos.org

Abstract

Background

Control of vascular risk factors is essential for secondary stroke prevention. However, adherence to secondary prevention medications is often suboptimal, and may be affected by cognitive impairment. Few studies to date have examined associations between cognitive impairment and medication adherence post-stroke, and none have considered whether adherence to secondary prevention medications might affect subsequent cognitive function. The aim of this study was to explore prospective associations between cognitive impairment and medication non-adherence post-stroke.

Methods

A five-year follow-up of 108 stroke survivors from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective observational cohort study. Cognitive function was assessed using the Montreal Cognitive Assessment at 6 months, and a neuropsychological test battery at 5 years. Adherence to antihypertensive, antithrombotic and lipid-lowering medications was assessed using prescription refill data.

Results

The prevalence of cognitive impairment at five years was 35.6%. The prevalence of non-adherence ranged from 15.1% for lipid-lowering agents to 30.2% for antithrombotics. There were no statistically significant associations between medication non-adherence in the first year post-stroke and cognitive impairment at 5 years, nor between cognitive impairment at 6 months and non-adherence at 5 years. Stroke survivors with cognitive impairment were significantly more likely to report receiving help with taking medications [OR (95% CI): 4.84 (1.17, 20.07)].

Conclusions

This is the first study to explore the potential impact of non-adherence to secondary prevention medications on cognitive impairment in stroke survivors. Findings highlight the role of family members and caregivers in assisting stroke survivors with medication administration, particularly in the context of deficits in cognitive function. Involving family members and caregivers may be a legitimate and cost-effective strategy to improve medication adherence in stroke survivors.

Disciplines

Behavior and Behavior Mechanisms | Cardiovascular Diseases | Clinical Epidemiology | Epidemiology | Geriatrics | Health Psychology | Neurology | Psychology

Citation

Rohde D, Gaynor E, Large M, Mellon L, Bennett K1, Williams DJ, Brewer L, Hall P, Callaly E, Dolan E, Hickey A. Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort. PLoS One. 2019;14(10):e0223997

PubMed ID

31622438

DOI Link

10.1371/journal.pone.0223997

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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