Perminder S. Sachdev, University of New South Wales
Jessica W. Lo, University of New South Wales
John D. Crawford, University of New South Wales
Lisa Mellon, Royal College of Surgeons in IrelandFollow
Anne Hickey, Royal College of Surgeons in IrelandFollow
David Williams, Royal College of Surgeons in IrelandFollow
Régis Bordet, University of Lille
Anne-Marie Mendyk, University of Lille
Patrick Gelé, University of Lille
Dominique Deplanque, University of Lille
Hee-Joon Bae, Seoul National University Bundang Hospital
Jae-Sung Lim, Hallym University Sacred Heart Hospital
Amy Brodtmann, University of Melbourne
Emilio Werden, University of Melbourne
Toby Cumming, University of Melbourne
Sebastian Köhler, Maastricht University
Frans RJ Verhey, Maastricht University
Yan-Hong Dong, University of New South Wales
Hui Hui Tan, National University of Singapore
Christopher Chen, National University of Singapore
Xu Xin, National University of Singapore
Raj N. Kalaria, Newcastle University
Louise M. Allan, Newcastle University
Rufus O. Akinyemi, University of Ibadan
Adesola Ogunniyi, University of Ibadan
Aleksandra Klimkowicz-Mrowiec, Jagiellonian University Medical College
Martin Dichgans, Ludwig-Maximilians-University
Frank A. Wollenweber, Ludwig-Maximilians-University
Vera Zietemann, Ludwig-Maximilians-University
Michael Hoffmann, University of Central Florida
David W. Desmond
Thomas Linden, University of Melbourne
Christian Blomstrand, University of Gothenburg
Björn Fagerberg, University of Gothenburg
Ingmar Skoog, University of Gothenburg
Olivier Godefroy, University of Amiens
Mélanie Barbay, University of Amiens
Martine Roussel, University of Amiens
Byung-Chul Lee, Hallym University Sacred Heart Hospital
Kyung-Ho Yu, Hallym University Sacred Heart Hospital
Joanna Wardlaw, University of Edinburgh
Stephen J. Makin, University of Glasgow
Fergus N. Doubal, University of Edinburgh
Francesca M. Chappell, University of Edinburgh
Velandai K. Srikanth, Monash University
Amanda G. Thrift, Monash University
Geoffrey A. Donnan, University of Melbourne
Nagaendran Kandiah, National Neuroscience Institute, Singapore
Russell J. Chander, National Neuroscience Institute, Singapore
Xuling Lin, National Neuroscience Institute, Singapore
Charlotte Cordonnier, University of Lille
Solene Moulin, University of Lille
Costanza Rossi, University of Lille
Behnam Sabayan, Leiden University Medical Centre
David J. Stott, University of Glasgow
J Wouter Jukema, Leiden University Medical Centre
Susanna Melkas, University of Helsinki
Hanna Jokinen, University of Helsinki
Timo Erkinjuntti, University of Helsinki
Vincent CT Mok, The Chinese University of Hong Kong
Adrian Wong, The Chinese University of Hong Kong
Bonnie YK Lam, The Chinese University of Hong Kong
Didier Leys, University of Lille
Hilde Hénon, University of Lille
Stéphanie Bombois, University of Lille
Darren M. Lipnicki, University of New South Wales
Nicole A. Kochan, University of New South Wales

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Cohort studies, Data harmonization, International consortium, Post-stroke dementia, Small vessel disease, Vascular cognitive disorder, Vascular dementia.


STROKOG: The Dementia Momentum fund from the Centre of Healthy Brain Ageing (CHeBA), UNSW Medicine, University of New South Wales and Vincent Fairfax Family Foundation. ASPIRE-S: Irish Health Research Board (HRB; grant number 1404/7400). CASPER and CODAS: Maastricht University, Health Foundation Limburg, and the Adriana van Rinsum-Ponsen Stichting. COAST: National Medical Research Council (NMRC/CG/NUHS/2010) and National University Health System National Clinician Scientist Program (NUHS NCSP). CogFAST-UK: Newcastle Centre for Brain Ageing and Vitality (BBSRC, EPSRC, ESRC and MRC, LLHW; G0700718). The original CogFAST-UK research programmes were supported by the UK Medical Research Council (MRC, G0500247 and G9817621). CogFAST-Nigeria: R.O.A. was supported by a fellowship from the International Brain Research Organization (IBRO) Paris, France and by an ORS Award from the Newcastle University, UK. DEDEMAS: Vascular Dementia Research Foundation. Flutemetamol (18F) was provided by GE Healthcare. Epi USA: National Institutes of Health (grants R01-NS26179 and P01-AG07232). GRECOG-VASC: French Health Ministry. MSS-II: Wellcome Trust number WT088134/Z/09/A.Row Fogo Trust. NEMESIS: NHMRC, Victorian Health Promotion Foundation, Austin Hospital Medical Research Foundation, Perpetual Trustees, National Stroke Foundation, Foundation for High Blood Pressure Research. NNI: National Neuroscience Institute, Singapore. PROSPER: The original PROSPER clinical trial was founded by an investigator initiated grant from Bristol-Myers Squibb, USA. SAM: Helsinki University Central Hospital, Helsinki. STRIDE: Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the HKSAR, the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Centre for Prevention of Dementia. SSS: National Health and Medical Research Council.


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INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).

METHODS: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.

RESULTS: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.

DISCUSSION: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.




Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk AM, Gelé P, Deplanque D, Bae HJ, Lim JS, Brodtmann A, Werden E, Cumming T, Köhler S, Verhey FR, Dong YH, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee BC, Yu KH, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VC, Wong A, Lam BY, Leys D, Hénon H, Bombois S, Lipnicki DM, Kochan NA; STROKOG. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016;7:11-23.

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