Aged, Cross-Sectional Studies, Drug-Related Side Effects and Adverse Reactions, Health Care Costs, Health Services, Humans, Ireland, Medication Adherence, Patient Admission, Patient Reported Outcome Measures, Prevalence, Prospective Studies, Quality of Life, Research Design, Risk Factors
Health Research Board Ireland (RL-2015-1579). RCSI StAR MD Programme.
INTRODUCTION: Older people experience greater morbidity with a corresponding increase in medication use resulting in a potentially higher risk of adverse drug reactions (ADRs). The aim of this study is to determine the prevalence and characteristics of ADR-related hospital admissions among older patients (≥65 years) and their associated health and cost outcomes.
METHODS AND ANALYSIS: The proposed study will include a cross-sectional study of ADR prevalence in all patients aged ≥65 years admitted acutely to a large tertiary referral hospital in Ireland over a 9-month period (2016-2017) and a prospective cohort study of patient-reported health outcomes and costs associated with ADR-related hospital admissions. All acute medical admissions will be screened for a suspected ADR-related hospital admission. A number of validated algorithms will be applied to assess the type, causative medications, preventability and severity of each ADR. ADRs will be determined, using a consensus method, by an expert panel. Patients who provide consent will be followed up 3 months post-discharge to establish patient-reported health outcomes (health service use, health-related quality of life, adherence) and costs associated with ADR-related hospital admissions. A random sample of patients admitted to hospital without a suspected ADR will be invited to take part in the study as a control group.
ETHICS AND DISSEMINATION: Ethical approval was obtained from Beaumont Hospital Ethics Committee. Findings will be disseminated through presentations and peer-reviewed publications.
Cahir C, Curran C, Byrne C, Walsh C, Hickey A, Williams DJ, Bennett K. Adverse Drug reactions in an Ageing PopulaTion (ADAPT) study protocol: a cross-sectional and prospective cohort study of hospital admissions related to adverse drug reactions in older patients. BMJ Open. 2017;7(6):e017322.
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