Peer Reviewed

1

Document Type

Article

Publication Date

10-5-2019

Keywords

Psychosis, clozapine, deteriorative disorder, negative, deficit syndrome.

Comments

"This is a non-final version of an article published in final form in Lally J, Maloudi S, Krivoy A, Murphy KC. Simple Schizophrenia: A Forgotten Diagnosis in Psychiatry. Journal of Nervous and Mental Disease. 2019 May 10"

Abstract

Clustering of symptoms to characterize simple schizophrenia is still debated, and support is needed for the characterization of simple schizophrenia as a syndrome. We conducted a systematic review to identify all cases of simple schizophrenia published until December 2017. We identified 42 cases of simple schizophrenia, 57% of which met all three diagnostic criteria (ICD-10, DSM-4 research criteria, and Black and Boffeli's criteria for simple schizophrenia). The mean age at first contact with clinical services was 30.1 (SD = 11.6) years, with a mean delay of 7.4 (SD = 6.8) years from symptom onset to first presentation. An insidious onset and negative symptoms were characteristic features in all cases. Social withdrawal, alogia, blunted affect, lack of initiative/interest, and functional impairment were found in more than 85% of cases. Our findings contribute to greater awareness and understanding of simple schizophrenia, and have the potential to reawaken interest in this clinically distinct subgroup.

Disciplines

Medicine and Health Sciences | Psychiatry and Psychology

Citation

Lally J, Maloudi S, Krivoy A, Murphy KC. Simple Schizophrenia: A Forgotten Diagnosis in Psychiatry. Journal of Nervous and Mental Disease. 2019;

PubMed ID

31082962

DOI Link

10.1097/NMD.0000000000000936

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Available for download on Friday, May 22, 2020

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