Title

Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies.

Authors

John Lally, Royal College of Surgeons in IrelandFollow
Olesya Ajnakina, King's College London
Brendon Stubbs, South London and Maudsley National Health Service (NHS) Foundation Trust
Michael Cullinane, St Fintan's Hospital, Portlaoise
Kieran C. Murphy, Royal College of Surgeons in IrelandFollow
Fiona Gaughran, King's College London
Robin M. Murray, South London and Maudsley NHS Foundation Trust

Peer Reviewed

1

Document Type

Article

Publication Date

1-12-2017

Keywords

Psychosis, Remission, Recovery, First-episode, Systematic Review, Adult.

Comments

This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at http://bjp.rcpsych.org

Abstract

Background: Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain.

Aims: To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators.

Method: We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators.

Results: Seventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions.

Conclusions: Remission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.

Disciplines

Medicine and Health Sciences | Psychiatry and Psychology

Citation

Lally J, Ajnakina O, Stubbs B, Cullinane M, Murphy KC, Gaughran F, Murray RM. Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies. British Journal of Psychiatry. 2017;211(6):350-358

PubMed ID

28982659

Link to this item at

https://epubs.rcsi.ie/psychart/73

DOI Link

10.1192/bjp.bp.117.201475

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.