Alkynes, Amino Acids, Azides, Blood Platelets, Epoxy Compounds, Humans, Peptides, Polyethylene Glycols, Polymers, Sulfhydryl Compounds
Irish Drug Delivery Network, Health Research Board
Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies.
Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences
O'Connor A, Marsat JN, Mitrugno A, Flahive T, Moran N, Brayden D, Devocelle M. Poly(Ethylene glycol)-based backbones with high peptide loading capacities. Molecules. 2014;19(11):17559-77
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