Peer Reviewed
1
Document Type
Article
Publication Date
7-9-2016
Keywords
Fluorescence imaging, BF2 azadipyrromethene fluorochrome
Abstract
The contribution of imaging with near infrared (NIR) fluorophores to the elucidation of complex biological processes continues to rapidly expand. New tools for mild selective bioconjugation are strongly desirable for the construction of NIR labelled biomolecules. This work presents the synthesis and evaluation of a strained alkyne substituted NIR BF2-azadipyrromethene (NIR-AZA) which can conjugate in water with azido-homoalanine and cRGD peptide within 30 min at rt. Imaging analysis of the NIR-AZA–cRGD conjugate in vitro and in vivo showed efficient cellular uptake and good in vivo tumor targeting properties, illustrating the potential for translation to clinical imaging.
Disciplines
Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences
Citation
Wu D, Cheung S, O'Sullivan CJ, Gao Y, Chen Zl, O'Shea DF. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances. 2016;6:87373-87379
Link to this item at
https://epubs.rcsi.ie/pmcart/25
DOI Link
http://dx.doi.org/10.1039/C6RA19843K
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Comments
The original paper is available at https://pubs.rsc.org