Peer Reviewed

1

Document Type

Article

Publication Date

7-9-2016

Keywords

Fluorescence imaging, BF2 azadipyrromethene fluorochrome

Comments

The original paper is available at https://pubs.rsc.org

Abstract

The contribution of imaging with near infrared (NIR) fluorophores to the elucidation of complex biological processes continues to rapidly expand. New tools for mild selective bioconjugation are strongly desirable for the construction of NIR labelled biomolecules. This work presents the synthesis and evaluation of a strained alkyne substituted NIR BF2-azadipyrromethene (NIR-AZA) which can conjugate in water with azido-homoalanine and cRGD peptide within 30 min at rt. Imaging analysis of the NIR-AZA–cRGD conjugate in vitro and in vivo showed efficient cellular uptake and good in vivo tumor targeting properties, illustrating the potential for translation to clinical imaging.

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences

Citation

Wu D, Cheung S, O'Sullivan CJ, Gao Y, Chen Zl, O'Shea DF. Strained alkyne substituted near infrared BF2 azadipyrromethene fluorochrome. RSC Advances. 2016;6:87373-87379

DOI Link

http://dx.doi.org/10.1039/C6RA19843K

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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