Peer Reviewed
1
Document Type
Article
Publication Date
31-3-2016
Keywords
Monolith Anchoring, Polymer Monoliths, Polypropylene Housing
Funder/Sponsor
This work was supported by funding from Science Foundation Ireland (07/IN1/B1792). M. I. gratefully acknowledges support from the Biomedical Diagnostic Institute (BDI) and the Irish Separation Science Cluster (ISSC)
Abstract
Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths.
Disciplines
Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences
Citation
Iacono M, Connolly D, Heise A. Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing. Materials. 2016;9:263.
PubMed ID
28773385
Link to this item at
http://epubs.rcsi.ie/pmcart/19/
DOI Link
10.3390/ma9040263
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Comments
This article is also available at http://www.mdpi.com/1996-1944/9/4/263