Peer Reviewed

1

Document Type

Article

Publication Date

1-12-2018

Keywords

Mucin pools, neoadjuvant treatment, radiotherapy, rectal cancer, response.

Comments

"This is the peer reviewed version of the following article:, Reynolds IS, McNamara DA, Kay EW, O’Neill B, Deasy J, Burke JP. The significance of mucin pools following neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Journal of Surgical Oncology. 2018;118:1129-1134, which has been published in final form at https://doi.org/10.1002/jso.25247 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."

Abstract

BACKGROUND: Neoadjuvant chemo-radiotherapy is utilized for locally advanced rectal cancer to optimize local control. A subset of patients form mucin pools following radiotherapy but the association between mucin pools and pathological and oncological outcomes following curative proctectomy for rectal cancer remains unknown.

OBJECTIVE: The aim of this study was to determine the significance of mucin pool formation after neoadjuvant chemoradiotherapy for rectal cancer.

METHODS: This is a retrospective analysis of a prospectively maintained rectal cancer database. Patients who underwent curative proctectomy for rectal cancer following long course chemoradiotherapy between January 2007 and December 2016 were eligible for inclusion.

RESULTS: A total of 297 patients were eligible for inclusion; of these 36 (12.1%) had mucin pools on final histopathology. Tumors with mucin pools were less likely to be ypT3/T4 (25.0 vs 51.0%, P = 0.003), were more likely to have a good response (83.3 vs 53.6%, P < 0.001) and more likely to have a pathologic complete response (41.7 vs 19.2%, P = 0.006) to radiotherapy. The presence of mucin pools was associated with less distant recurrence ( P < 0.05) and improved overall survival ( P = 0.02).

CONCLUSIONS: The presence of mucin pools following neoadjuvant chemoradiotherapy for rectal cancer represents a surrogate marker of response to treatment and downstaging and is associated with improved survival.

Disciplines

Physics | Physiology

Citation

Reynolds IS, McNamara DA, Kay EW, O’Neill B, Deasy J, Burke JP. The significance of mucin pools following neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Journal of Surgical Oncology. 2018;118:1129-1134

PubMed ID

30261095

DOI Link

10.1002/jso.25247

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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