Peer Reviewed

1

Document Type

Article

Publication Date

1-1-2017

Keywords

Brain Neoplasms, Glioblastoma, Humans, Immunotherapy

Funder/Sponsor

Irish Cancer Society Research Fellowship CRF13TIV, Science Foundation Ireland (SFI) under Grant Number 12/IA/1421 and the SFI Research Centre, Advanced Materials and BioEngineering Research (AMBER) under Grant Number SFI/12/RC/2278. Science Foundation Ireland (14/IA/2582)

Comments

This article is available at https://link.springer.com/

Abstract

Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, harnessing the power of the host's immune system to reject cancer cells. Key challenges in glioma specific immunotherapy as with many other cancers are the limited immunogenicity of the cancer cells and the immunosuppressive environment of the tumour. Although specific antigens have been identified in several cancers; brain tumours, such as GBM, are considered poorly immunogenic. However, as detailed in this review, strategies aimed at circumventing these challenges are showing promise for GBM treatment; including identification of glioma specific antigens and endogenous immune cell activation in an attempt to overcome the immunosuppressive environment which is associated with GBM tumours. An up-to-date summary of current Phase I/II and ongoing Phase III GBM immunotherapy clinical trials is provided in addition to insights into promising preclinical approaches which are focused predominantly on increased induction of Type 1 helper T cell (T

Disciplines

Physics | Physiology

Citation

Tivnan A, Heilinger T, Lavelle EC, Prehn JH. Advances in immunotherapy for the treatment of glioblastoma. Journal of neuro-oncology. 2017;131(1):1-9

PubMed ID

27743144

DOI Link

10.1007/s11060-016-2299-2

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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