Authors

Lorenzo Galluzzi, Weill Cornell Medical College
Ilio Vitale, University of Rome "Tor Vergata"
Stuart A Aaronson, Icahn School of Medicine at Mount Sinai
John M Abrams, University of Texas Southwestern Medical Center
Dieter Adam, Kiel University
Patrizia Agostinis, Kiel University
Emad S Alnemri, Thomas Jefferson University
Lucia Altucci, University of Campania "Luigi Vanvitelli"
Ivano Amelio, Leicester University
David W Andrews, Sunnybrook Research Institute
Margherita Annicchiarico-Petruzzelli, Dermopatic Institute of Immaculate (IDI) IRCCS
Alexey V Antonov, Leicester University
Eli Arama, Weizmann Institute of Science
Eric H Baehrecke, University of Massachusetts Medical School
Nickolai A Barlev, Russian Academy of Sciences
Nicolas G Bazan, Louisiana State University School of Medicine
Francesca Bernassola, University of Rome "Tor Vergata"
Mathieu J M Bertrand, VIB Center for Inflammation Research (IRC)
Katiuscia Bianchi, Queen Mary University of London
Mikhail V Blagosklonny, Roswell Park Cancer Institute
Klas Blomgren, Karolinska Institute
Christoph Borner, Albert Ludwigs University
Patricia Boya, Spanish National Research Council (CSIC)
Catherine Brenner, Châtenay Malabry
Michelangelo Campanella, University of Rome "Tor Vergata"
Eleonora Candi, Dermopatic Institute of Immaculate (IDI)
Didac Carmona-Gutierrez, University of Graz
Francesco Cecconi, University of Rome "Tor Vergata"
Francis K-M Chan, University of Massachusetts Medical School
Navdeep S Chandel, Northwestern University Feinberg School of Medicine
Emily H Cheng, Memorial Sloan Kettering Cancer Center
Jerry E Chipuk, Icahn School of Medicine at Mount Sinai
John A Cidlowski, National Institutes of Environmental Health Sciences
Aaron Ciechanover, Technion-Israel Institute of Technology
Gerald M Cohen, University of Liverpool
Marcus Conrad, German Research Center for Environmental Health (GmbH)
Juan R Cubillos-Ruiz, Sandra and Edward Meyer Cancer Center
Peter E Czabotar, The Walter and Eliza Hall Institute of Medical Research
Vincenzo D'Angiolella, University of Oxford
Ted M Dawson, Johns Hopkins University School of Medicine
Valina L Dawson, Johns Hopkins University School of Medicine
Vincenzo De Laurenzi, Johns Hopkins University School of Medicine
Ruggero De Maria, Catholic University "Sacro Cuore"
Klaus-Michael Debatin, Ulm University Medical Center
Ralph J DeBerardinis, University of Texas Southwestern Medical Center
Mohanish Deshmukh, University of North Carolina
Nicola Di Daniele, University of Rome "Tor Vergata"
Francesco Di Virgilio, University of Ferrara
Vishva M Dixit
Scott J Dixon
Colin S Duckett
Brian D Dynlacht
Wafik S El-Deiry
John W Elrod
Gian Maria Fimia
Simone Fulda
Ana J García-Sáez
Abhishek D Garg
Carmen Garrido
Evripidis Gavathiotis
Pierre Golstein
Eyal Gottlieb
Douglas R Green
Lloyd A Greene
Hinrich Gronemeyer
Atan Gross
Gyorgy Hajnoczky
J Marie Hardwick
Isaac S Harris
Michael O Hengartner
Claudio Hetz
Hidenori Ichijo
Marja Jäättelä
Bertrand Joseph
Philipp J Jost
Philippe P Juin
William J Kaiser
Michael Karin
Thomas Kaufmann
Oliver Kepp
Adi Kimchi
Richard N Kitsis
Daniel J Klionsky
Richard A Knight
Sharad Kumar
Sam W Lee
John J Lemasters
Beth Levine
Andreas Linkermann
Stuart A Lipton
Richard A Lockshin
Carlos López-Otín
Scott W Lowe
Tom Luedde
Enrico Lugli
Marion MacFarlane
Frank Madeo
Michal Malewicz
Walter Malorni
Gwenola Manic
Jean-Christophe Marine
Seamus J Martin
Jean-Claude Martinou
Jan Paul Medema
Patrick Mehlen
Pascal Meier
Sonia Melino
Edward A Miao
Jeffery D Molkentin
Ute M Moll
Cristina Muñoz-Pinedo
Shigekazu Nagata
Gabriel Nuñez
Andrew Oberst
Moshe Oren
Michael Overholtzer
Michele Pagano
Theocharis Panaretakis
Manolis Pasparakis
Josef M Penninger
David M Pereira
Shazib Pervaiz
Marcus E Peter
Mauro Piacentini
Paolo Pinton
Jochen H M Prehn, Royal College of Surgeons in IrelandFollow
Hamsa Puthalakath
Gabriel A Rabinovich
Markus Rehm
Rosario Rizzuto
Cecilia M P Rodrigues
David C Rubinsztein
Thomas Rudel
Kevin M Ryan
Emre Sayan
Luca Scorrano
Feng Shao
Yufang Shi
John Silke
Hans-Uwe Simon
Antonella Sistigu
Brent R Stockwell
Andreas Strasser
Gyorgy Szabadkai
Stephen W G Tait
Daolin Tang
Nektarios Tavernarakis
Andrew Thorburn
Yoshihide Tsujimoto
Boris Turk
Tom Vanden Berghe
Peter Vandenabeele
Matthew G Vander Heiden
Andreas Villunger
Herbert W Virgin
Karen H Vousden
Domagoj Vucic
Erwin F Wagner
Henning Walczak
David Wallach
Ying Wang
James A Wells
Will Wood
Junying Yuan
Zahra Zakeri
Boris Zhivotovsky
Laurence Zitvogel
Gerry Melino
Guido Kroemer

Peer Reviewed

1

Document Type

Article

Publication Date

1-3-2018

Keywords

Cell Death, Guidelines, Nomenclature

Funder/Sponsor

e Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF_GR-2011-02351355)

Comments

This article is available from https://www.nature.com

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Disciplines

Physics | Physiology

Citation

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation. 2018; 25(3):486-541

PubMed ID

29362479

DOI Link

10.1038/s41418-017-0012-4

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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