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Submissions from 2019

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When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?, Anne-Marie Baird, David Easty, Monika A. Jarzabek, Liam Shiels, Alex Soltermann, Sonja Klebe, Stéphane Raeppel, Lauren MacDonagh, Chengguang Wu, Kim Griggs, Michaela B. Kirschner, Bryan Stanfill, Daisuke Nonaka, Chandra M. Goparaju, Bruno Murer, Dean A. Fennell, Dearbhaile M. O'Donnell, Martin P. Barr, Luciano Mutti, Glen Reid, Stephen Finn, Sinead Cuffe, Harvey I. Pass, Isabelle Opitz, Annette Byrne, Kenneth J. O'Byrne, and Steven G. Gray

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RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells., Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice C. O'Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette Byrne, and Wim E. Hennink

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Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents., Ian S. Miller, Liam Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M Gallagher, Norma O'Donovan, Robert S. Kerbel, John Crown, and Annette Byrne

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Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate., Alice C. O'Farrell, Ian S. Miller, Rhys Evans, Marina Alamanou, Maurice Cary, Girish Mallya Udupi, Adam Lafferty, Naser Monsefi, Mattia Cremona, Jochen HM Prehn, Henk M. Verheul, William M. Gallagher, Mathias Gehrmann, and Annette Byrne

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Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers., Ian S. Reynolds, Michael Fichtner, Deborah A. McNamara, Elaine W. Kay, Jochen HM Prehn, and John P. Burke

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HCP: A Matlab package to create beautiful heatmaps with richly annotated covariates, Manuela Salvucci and Jochen HM Prehn

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A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic., Manuela Salvucci, Arman Rahman, Alexa J. Resler, Girish M. Udupi, Deborah A. McNamara, Elaine W. Kay, Pierre Laurent-Puig, Daniel B. Longley, Patrick G. Johnston, Mark Lawler, Richard Wilson, Manuel Salto-Tellez, Sandra Van Schaeybroeck, Mairin Rafferty, William M. Gallagher, Markus Rehm, and Jochen HM Prehn

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Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons., Pierre Theurey, Niamh M. Connolly, Ilaria Fortunati, Emy Basso, Susette Lauwen, Camilla Ferrante, Catarina Moreira Pinho, Alvin Joselin, Anna Gioran, Daniele Bano, David S. Park, Maria Ankarcrona, Paola Pizzo, and Jochen HM Prehn

Submissions from 2018

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The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer., Steven Carberry, Beatrice D'Orsi, Naser Monsefi, Manuela Salvucci, Orna Bacon, Joanna Fay, Markus Rehm, Deborah A. McNamara, Elaine W. Kay, and Jochen H M Prehn

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Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711., Nyree Crawford, Manuela Salvucci, Christian T. Hellwig, Frank A. Lincoln, Ruth E. Mooney, Carla L O'Connor, Jochen HM Prehn, Daniel B Longley, and Markus Rehm

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Pleiotropic activity of systemically delivered angiogenin in the SOD1, Martin Crivello, Saidhbhe L. O'Riordan, Ina Woods, Sarah Cannon, Luise Halang, Karen S. Coughlan, Marion C. Hogg, Sebastian A. Lewandowski, and Jochen HM Prehn

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018., Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V Antonov, Eli Arama, Eric H Baehrecke, Nickolai A Barlev, Nicolas G Bazan, Francesca Bernassola, Mathieu J M Bertrand, Katiuscia Bianchi, Mikhail V Blagosklonny, Klas Blomgren, Christoph Borner, Patricia Boya, Catherine Brenner, Michelangelo Campanella, Eleonora Candi, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Navdeep S Chandel, Emily H Cheng, Jerry E Chipuk, John A Cidlowski, Aaron Ciechanover, Gerald M Cohen, Marcus Conrad, Juan R Cubillos-Ruiz, Peter E Czabotar, Vincenzo D'Angiolella, Ted M Dawson, Valina L Dawson, Vincenzo De Laurenzi, Ruggero De Maria, Klaus-Michael Debatin, Ralph J DeBerardinis, Mohanish Deshmukh, Nicola Di Daniele, Francesco Di Virgilio, Vishva M Dixit, Scott J Dixon, Colin S Duckett, Brian D Dynlacht, Wafik S El-Deiry, John W Elrod, Gian Maria Fimia, Simone Fulda, Ana J García-Sáez, Abhishek D Garg, Carmen Garrido, Evripidis Gavathiotis, Pierre Golstein, Eyal Gottlieb, Douglas R Green, Lloyd A Greene, Hinrich Gronemeyer, Atan Gross, Gyorgy Hajnoczky, J Marie Hardwick, Isaac S Harris, Michael O Hengartner, Claudio Hetz, Hidenori Ichijo, Marja Jäättelä, Bertrand Joseph, Philipp J Jost, Philippe P Juin, William J Kaiser, Michael Karin, Thomas Kaufmann, Oliver Kepp, Adi Kimchi, Richard N Kitsis, Daniel J Klionsky, Richard A Knight, Sharad Kumar, Sam W Lee, John J Lemasters, Beth Levine, Andreas Linkermann, Stuart A Lipton, Richard A Lockshin, Carlos López-Otín, Scott W Lowe, Tom Luedde, Enrico Lugli, Marion MacFarlane, Frank Madeo, Michal Malewicz, Walter Malorni, Gwenola Manic, Jean-Christophe Marine, Seamus J Martin, Jean-Claude Martinou, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Sonia Melino, Edward A Miao, Jeffery D Molkentin, Ute M Moll, Cristina Muñoz-Pinedo, Shigekazu Nagata, Gabriel Nuñez, Andrew Oberst, Moshe Oren, Michael Overholtzer, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M Penninger, David M Pereira, Shazib Pervaiz, Marcus E Peter, Mauro Piacentini, Paolo Pinton, Jochen H M Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Markus Rehm, Rosario Rizzuto, Cecilia M P Rodrigues, David C Rubinsztein, Thomas Rudel, Kevin M Ryan, Emre Sayan, Luca Scorrano, Feng Shao, Yufang Shi, John Silke, Hans-Uwe Simon, Antonella Sistigu, Brent R Stockwell, Andreas Strasser, Gyorgy Szabadkai, Stephen W G Tait, Daolin Tang, Nektarios Tavernarakis, Andrew Thorburn, Yoshihide Tsujimoto, Boris Turk, Tom Vanden Berghe, Peter Vandenabeele, Matthew G Vander Heiden, Andreas Villunger, Herbert W Virgin, Karen H Vousden, Domagoj Vucic, Erwin F Wagner, Henning Walczak, David Wallach, Ying Wang, James A Wells, Will Wood, Junying Yuan, Zahra Zakeri, Boris Zhivotovsky, Laurence Zitvogel, Gerry Melino, and Guido Kroemer

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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation., Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König, and Jochen HM Prehn

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BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose., Federico Lucantoni, Heiko Düssmann, Irene Llorente-Folch, and Jochen HM Prehn

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Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1., Federico Lucantoni, Heiko Düssmann, and Jochen HM Prehn

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Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells., Federico Lucantoni, Andreas U Lindner, Norma O'Donovan, Heiko Düssmann, and Jochen HM Prehn

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Systemic delivery of selective EP1 and EP3 receptor antagonists attenuates pentylenetetrazole-induced seizures in mice., Cristina R Reschke, Alice B. Poersch, Cíntia J. Masson, Ana C. Jesse, Joseane RR Marafiga, Quéli F. Lenz, Mauro S. Oliveira, David C. Henshall, and Carlos F. Mello

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The significance of mucin pools following neoadjuvant chemoradiotherapy for locally advanced rectal cancer., Ian S. Reynolds, Deborah A. McNamara, Elaine W. Kay, Brian O'Neill, Joseph Deasy, and John P. Burke

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Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma., Jan Rožanc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano Guttà, Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, and Leonidas G. Alexopoulos

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Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma., Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, and Markus Rehm

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Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy., Dominiek Smeets, Ian S. Miller, Darran P. O'Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole CT van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamara, Elaine W. Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen HM Prehn, Miriam Koopman, Cornelis JA Punt, Fotios Loupakis, Matthias PA Ebert, Bauke Ylstra, Diether Lambrechts, and Annette Byrne

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Anti-angiogenic drug scheduling optimisation with application to colorectal cancer., Marc Sturrock, Ian S. Miller, Guiyeom Kang, N Hannis Arba'ie, Alice C. O'Farrell, Ana Barat, Gemma Marston, Patricia L. Coletta, Annette Byrne, and Jochen HM Prehn

Submissions from 2017

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Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform., Ujval Anilkumar, Petronela Weisova, Jasmin Schmid, Tytus Bernas, Heinrich J. Huber, Heiko Düssmann, Niamh M. Connolly, and Jochen HM Prehn

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The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy., Edward Beamer, Wolfgang Fischer, and Tobias Engel

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Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases., Niamh M. Connolly, Pierre Theurey, Vera Adam-Vizi, Nicolas G. Bazan, Paolo Bernardi, Juan P. Bolaños, Carsten Culmsee, Valina L. Dawson, Mohanish Deshmukh, Michael R. Duchen, Heiko Düssmann, Gary Fiskum, Maria F. Galindo, Giles E. Hardingham, J Marie Hardwick, Mika B. Jekabsons, Elizabeth A. Jonas, Joaquin Jordán, Stuart A. Lipton, Giovanni Manfredi, Mark P. Mattson, BethAnn McLaughlin, Axel Methner, Anne N. Murphy, Michael P. Murphy, David G. Nicholls, Brian M. Polster, Tullio Pozzan, Rosario Rizzuto, Jorgina Satrústegui, Ruth S. Slack, Raymond A. Swanson, Russell H. Swerdlow, Yvonne Will, Zheng Ying, Alvin Joselin, Anna Gioran, Catarina Moreira Pinho, Orla Watters, Manuela Salvucci, Irene Llorente-Folch, David S. Park, Daniele Bano, Maria Ankarcrona, Paola Pizzo, and Jochen HM Prehn

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Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok., Beatrice D'Orsi, Julia Mateyka, and Jochen HM Prehn

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Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release, Heiko Düssmann, Sergio Perez-Alvarez, Ujval Anilkumar, Dmitri B Papkovsky, and Jochen HM Prehn

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Targeting the proteasome in epilepsy., Tobias Engel, Jose J Lucas, and David C. Henshall

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Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury., Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Yasmina Hernández-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas, and David C. Henshall

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The role of B cell antigen receptors in mantle cell lymphoma., Michael Fichtner, Martin Dreyling, Mascha Binder, and Martin Trepel

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Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome., Annika Hantusch, Thomas Brunner, Tancred Frickey, and Markus Rehm

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miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions., Stefan J. Haunsberger, Niamh M. Connolly, and Jochen HM Prehn

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Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice., Naoki Ichikawa, Mariana Alves, Shona Pfeiffer, Elena Langa, Yasmina Hernández-Santana, Hidenori Suzuki, Jochen Hm Prehn, Tobias Engel, and David C Henshall

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NF-κB regulates neuronal ankyrin-G via a negative feedback loop., Hans-Georg König, Robert Schwamborn, Silke Andresen, Sinéad Kinsella, Orla Watters, Beau Fenner, and Jochen HM Prehn

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"TORNADO" - Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid., Hazel McArdle, Eva M Jimenez-Mateos, Rana Raoof, Eadaoin Carthy, David Boyle, Hany ElNaggar, Norman Delanty, Hajo Hamer, Muejgdan Dogan, Tessa Huchtemann, Peter Kӧrtvelyessy, Felix Rosenow, Robert J Forster, David C Henshall, and Elaine Spain

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SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival., Beatrice Mohelnikova-Duchonova, Ondrej Strouhal, David J. Hughes, Ivana Holcatova, Martin Oliverius, Zdenek Kala, Daniele Campa, Cosmeri Rizzato, Federico Canzian, Raffaele Pezzilli, Renata Talar-Wojnarowska, Ewa Malecka-Panas, Cosimo Sperti, Carlo Federico Zambon, Sergio Pedrazzoli, Paola Fogar, Anna Caterina Milanetto, Gabriele Capurso, Gianfranco Delle Fave, Roberto Valente, Maria Gazouli, Giuseppe Malleo, Rita Teresa Lawlor, Oliver Strobel, Thilo Hackert, Nathalia Giese, Pavel Vodicka, Ludmila Vodickova, Stefano Landi, Francesca Tavano, Domenica Gioffreda, Ada Piepoli, Valerio Pazienza, Andrea Mambrini, Mariangela Pedata, Maurizio Cantore, Franco Bambi, Stefano Ermini, Niccola Funel, Radmila Lemstrova, and Pavel Soucek

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RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis., Claire M Mooney, Eva M Jimenez-Mateos, Tobias Engel, Catherine Mooney, Mairead Diviney, Morten T Venø, Jørgen Kjems, Michael A Farrell, Donncha F O'Brien, Norman Delanty, and David C Henshall

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Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach., Bruce Moran, Sudipto Das, Dominiek Smeets, Gillian Peutman, Ruth Klinger, Bozena Fender, Kate Connor, Matthias Ebert, Timo Gaiser, Jochen HM Prehn, Orna Bacon, Elaine W. Kay, Bryan T. Hennessy, Verena Murphy, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne, William M Gallagher, and Darran P. O'Connor

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A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate., Alice C. O'Farrell, Rhys Evans, Johanna MU Silvola, Ian S. Miller, Emer Conroy, Suzanne Hector, Maurice Cary, David W. Murray, Monika A. Jarzabek, Ashwini Maratha, Marina Alamanou, Girish Mallya Udupi, Liam Shiels, Celine Pallaud, Antti Saraste, Heidi Liljenbäck, Matti Jauhiainen, Vesa Oikonen, Axel Ducret, Paul Cutler, Fionnuala M McAuliffe, Jacques A Rousseau, Roger Lecomte, Suzanne Gascon, Zoltan Arany, Bonnie Ky, Thomas Force, Juhani Knuuti, William M. Gallagher, Anne Roivainen, and Annette T. Byrne

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Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus., Rana Raoof, Eva M Jimenez-Mateos, Sebastian Bauer, Björn Tackenberg, Felix Rosenow, Johannes Lang, Müjgan Dogan Onugoren, Hajo Hamer, Tessa Huchtemann, Peter Körtvélyessy, Niamh M C Connolly, Shona Pfeiffer, Jochen H M Prehn, Donncha F O'Brien, David C Henshall, and Catherine Mooney

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Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy., Cristina R. Reschke, Luiz FA Silva, Braxton A. Norwood, Ketharini Senthilkumar, Gareth Morris, Amaya Sanz-Rodriguez, Ronán Conroy, Lara Costard, Valentin Neubert, Sebastian Bauer, Michael A. Farrell, Donncha F. O'Brien, Norman Delanty, Stephanie Schorge, R Jeroen Pasterkamp, Felix Rosenow, and David C. Henshall

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A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer., Manuela Salvucci, Maximilian L. Würstle, Clare Morgan, Sarah Curry, Mattia Cremona, Andreas U. Lindner, Orna Bacon, Alexa J. Resler, Áine C. Murphy, Robert O'Byrne, Lorna Flanagan, Sonali Dasgupta, Nadege Rice, Camilla Pilati, Elisabeth Zink, Lisa M. Schöller, Sinead Toomey, Mark Lawler, Patrick G. Johnston, Richard Wilson, Sophie Camilleri-Broët, Manuel Salto-Tellez, Deborah A. McNamara, Elaine W. Kay, Pierre Laurent-Puig, Sandra Van Schaeybroeck, Bryan T. Hennessy, Daniel b. Longley, Markus Rehm, and Jochen HM Prehn

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The influence of nuclear compartmentalisation on stochastic dynamics of self-repressing gene expression., Marc Sturrock, Shiyu Li, and Vahid Shahrezaei

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Advances in immunotherapy for the treatment of glioblastoma., Amanda Tivnan, Tatjana Heilinger, Ed C Lavelle, and Jochen H.M. Prehn

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Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells., Amanda Tivnan, Tatjana Heilinger, Joanne M Ramsey, Gemma O'Connor, Jenny L Pokorny, Jann N Sarkaria, Brett W Stringer, Bryan W Day, Andrew W Boyd, Ella L Kim, Holger N Lode, Sally-Ann Cryan, and Jochen H.M. Prehn

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Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer., Linda Zuurbier, Arman Rahman, Martijn Cordes, Jennifer Scheick, Tse J. Wong, François Rustenburg, Jesu C. Joseph, Peter Dynoodt, Rory Casey, Paul Drillenburg, Michael Gerhards, Ana Barat, Rut Klinger, Bozena Fender, Darran P. O'Connor, Johannes Betge, Matthias P. Ebert, Timo Gaiser, Jochen HM Prehn, Arjan W. Griffioen, Nicole CT van Grieken, Bauke Ylstra, Annette Byrne, Laurens G. van der Flier, William M. Gallagher, and Ruben Postel

Submissions from 2016

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Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements., Maximilian O Besenhard, Monika Jarzabek, Alice C. O'Farrell, John J. Callanan, Jochen HM Prehn, Annette T. Byrne, and Heinrich J. Huber

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Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer., Karen Boland, Lorna Flanagan, Niamh McCawley, Ritesh Pabari, Elaine W. Kay, Deborah A. McNamara, Frank Murray, Annette Byrne, Zebunnissa Ramtoola, Caoimhín Concannon, and Jochen Prehn

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Community challenges when using large plastic bottles for Solar Energy Disinfection of Water (SODIS)., Preeti Borde, Khalifa Elmusharaf, Kevin G. McGuigan, and Michael B. Keogh

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Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions., Niamh MC Connolly, Beatrice D'Orsi, Naser Monsefi, Heinrich J. Huber, and Jochen HM Prehn

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Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury., Beatrice D'Orsi, Tobias Engel, Shona Pfeiffer, Saheli Nandi, Thomas Kaufmann, David C. Henshall, and Jochen HM Prehn

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Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach., Lorna Flanagan, M Meyer, Joanna Fay, Sarah Curry, Orna Bacon, Heiko Düssmann, Katharina John, Karen C. Boland, Deborah A. McNamara, Elaine W. Kay, Heike Bantel, Henning Schulze-Bergkamen, and Jochen HM Prehn

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MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset., Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W Danielson, Kristen T Thomas, Eva M Jimenez-Mateos, Lindsay M Schroeder, Raymund Y K Pun, Steve C Danzer, David C Henshall, and Gary J Bassell

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Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy., Alba Jimenez-Pacheco, Miguel Diaz-Hernandez, Marina Arribas-Blázquez, Amaya Sanz-Rodriguez, Luis A. Olivos-Oré, Antonio R. Artalejo, Mariana Alves, Michael Letavic, M Teresa Miras-Portugal, Ronán Conroy, Norman Delanty, Michael A. Farrell, Donncha F. O'Brien, Anindya Bhattacharya, Tobias Engel, and David C. Henshall

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Colorectal tumour simulation using agent based modelling and high performance computing, Guiyeom Kang, Claudio Márquez, Ana Barat, Annette T. Byrne, Jochen HM Prehn, Joan Sorribes, and Eduardo César

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Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia., Sinéad Kinsella, Hans-Georg König, and Jochen HM Prehn

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BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume., Nellie A. Martin, Helena Bonner, Maria L. Elkjær, Beatrice D'Orsi, Gang Chen, Hans-Georg König, Martina Svensson, Tomas Deierborg, Shona Pfeiffer, Jochen HM Prehn, and Kate L. Lambertsen

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A study of the bacteriological quality of roof-harvested rainwater and an evaluation of SODIS as a suitable treatment technology in rural Sub-Saharan Africa, R Nalwanga, C K. Muyanja, Kevin G. McGuigan, and B Quilty

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Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis., Katie Nolan, Franziska Walter, Liam P. Tuffy, Simone Poeschel, Ross Gallagher, Stefan Haunsberger, Isabella Bray, Raymond L. Stallings, Caoimhín G. Concannon, and Jochen HM Prehn

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Mechanistic interrogation of combination Bevacizumab/dual PI3K/mTOR inhibitor response in Glioblastoma implementing novel MR and PET imaging biomarkers., Philip J. O'Halloran, Thomas Viel, David W. Murray, Lydia Wachsmuth, Katrin Schwegmann, Stefan Wagner, Klaus Kopka, Monika A. Jarzabek, Patrick Dicker, Sven Hermann, Cornelius Faber, Tim Klasen, Michael Schäfers, David O'Brien, Jochen HM Prehn, Andreas H. Jacobs, and Annette T. Byrne

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AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection., Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, and Joachim Reischl

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Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer., Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhín G. Concannon, Elaine W. Kay, Deborah A. McNamara, and Jochen HM Prehn

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Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer., Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhín G. Concannon, Elaine W. Kay, Deborah A. McNamara, and Jochen HM Prehn

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The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer., Sinead Toomey, Stephen F Madden, Simon J Furney, Yue Fan, Mark McCormack, Carragh Stapleton, Mattia Cremona, Gianpiero L. Cavalleri, Malgorzata Milewska, Naomi Elster, Aoife Carr, Joanna Fay, Elaine W. Kay, Susan Kennedy, John Crown, William M Gallagher, Bryan T. Hennessy, and Alex J Eustace

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Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide., Birgit C. Weyhenmeyer, Janis Noonan, Maximilian L. Würstle, Frank A. Lincoln, Grainne Johnston, Markus Rehm, and Brona M. Murphy

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Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant., Zaitun Zakaria, Amanda Tivnan, Lorna Flanagan, David W. Murray, Manuela Salvucci, Brett W. Stringer, Bryan W. Day, Andrew W. Boyd, Donat Kögel, Markus Rehm, Donncha F. O'Brien, Annette Byrne, and Jochen HM Prehn

Submissions from 2015

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Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression., Sinéad T. Aherne, Stephen F. Madden, David J. Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling, and Martin Clynes

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MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise., Siobhán Bacon, Britta Engelbrecht, Jasmin Schmid, Shona Pfeiffer, Ross Gallagher, Ailbhe McCarthy, Marie Burke, Caoimhín Concannon, Jochen HM Prehn, and Maria M. Byrne

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Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications, Ana Barat, Heather J. Ruskin, Annette T. Byrne, and Jochen HM Prehn

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The metabolic response to excitotoxicity - lessons from single-cell imaging., Niamh M. Connolly and Jochen HM Prehn

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"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice., Karen S. Coughlan, Mollie R. Mitchem, Marion C. Hogg, and Jochen HM Prehn

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Bax regulates neuronal Ca2+ homeostasis, Beatrice D'Orsi, Seán M. Kilbride, Gang Chen, Sergio Perez Alvarez, Helena Bonner, Shona Pfeiffer, Nikolaus Plesnila, Tobias Engel, David C. Henshall, Heiko Düssmann, and Jochen HM Prehn

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High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer., Lorna Flanagan, Joan Kehoe, Joanna Fay, Orna Bacon, Andreas U. Lindner, Elaine W. Kay, Joseph Deasy, Deborah A. McNamara, and Jochen HM Prehn

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Capability of 19-litre polycarbonate plastic water cooler containers for efficient solar water disinfection (SODIS): field case studies in India, Bahrain and Spain., Michael B. Keogh, M Castro-Alférez, M I. Polo-López, I Fernández Calderero, Y A. Al-Eryani, C Joseph-Titus, B Sawant, R Dhodapkar, C Mathur, Kevin G. McGuigan, and P Fernández-Ibáñez

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BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes, Shona L. Pfeiffer, Luise Halang, Heiko Düssmann, Maria M. Byrne, and Jochen Prehn

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The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival., Shona L. Pfeiffer and Jochen Prehn

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Transcriptional response of polycomb group genes to status epilepticus in mice is modified by prior exposure to epileptic preconditioning., James P. Reynolds, Suzanne FC Miller-Delaney, Eva M. Jimenez-Mateos, Takanori Sano, Ross C. McKiernan, Roger P. Simon, and David C. Henshall

Submissions from 2014

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Anti-apoptotic BCL-2 family proteins in acute neural injury., Ujval Anilkumar and Jochen HM Prehn

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Comparison of performance in a four year graduate entry medical programme and a traditional five/six year programme., Annette T. Byrne, Richard Arnett, Tom Farrell, and Seamus Sreenan

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Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development., Jayne C. Carberry, Clodagh McMorrow, Aidan Bradford, James FX Jones, and Ken d. O'Halloran

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Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation, Niamh M. Connolly, Heiko Düssmann, Ujval Anilkumar, Heinrich J. Huber, and Jochen HM Prehn

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Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways., Maria Eugenia Delgado, Lydia Dyck, Maike A. Laussmann, and Markus Rehm

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Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome., Lorna Flanagan, Jasmin Schmid, Matthias Ebert, Pavel Soucek, Tereza Kunicka, Vaclav Liska, Jan Bruha, Paul Neary, Nicki Dezeeuw, Massimo Tommasino, Mazda Jenab, Jochen HM Prehn, and David J. Hughes

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Patient-derived xenograft models: an emerging platform for translational cancer research., Manuel Hidalgo, Frederic Amant, Andrew V. Biankin, Eva Budinská, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Steven de Jong, Jos Jonkers, Gunhild Mari Mælandsmo, Sergio Roman-Roman, Joan Seoane, Livio Trusolino, and Alberto Villanueva

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Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort, David J. Hughes, Veronika Fedirko, Mazda Jenab, Lutz Schomburg, Catherine Meplan, Heinz Freisling, H B. Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tjonneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kuhn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H. Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose Sanchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E. Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramon Quiros, Magdalena Stepien, So Y. Kong, Talita Duarte-Salles, Elio Riboli, and John E. Hesketh

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Solar photocatalysis for water disinfection: Materials and reactor design, Donal A. Keane, Kevin G. McGuigan, Pilar Fernandez Ibanez, M Inmaculada Polo-Lopez, Anthony J. Byrne, Patrick SM Dunlop, Kevin O'Shea, Dionysios D. Dionysiou, and Suresh C. Pillai

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The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes., Hans-Georg König, Karen S. Coughlan, Sinéad Kinsella, Bridget A. Breen, and Jochen HM Prehn

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Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis., Áine C. Murphy, Birgit Weyhenmeyer, Janis Noonan, Seán M. Kilbride, Sarah Schimansky, Kah P. Loh, D Kögel, A G. Letai, Jochen HM Prehn, and Brona M. Murphy

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Evaluation of Solar Disinfection of E. coli Under Sub-Saharan Field Conditions Using a 25 Litre Borosilicate Glass Batch Reactor Fitted with a Compound Parabolic Collector., R Nalwanga, B Quilty, C Muyanja, P Fernández Ibáñez, and Kevin G. McGuigan

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Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury., Shona Pfeiffer, Ujval Anilkumar, Gang Chen, S Ramírez-Peinado, J Galindo-Moreno, C Muñoz-Pinedo, and Jochen HM Prehn

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Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis., Lavanya Ramapathiran, Tytus Bernas, Franziska Walter, Linda Williams, Heiko Düssmann, Caoimhín G. Concannon, and Jochen HM Prehn

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De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP., Caroline Sheedy, Claire Mooney, Eva Jimenez-Mateos, Amaya Sanz-Rodriguez, Elena Langa, Catherine Mooney, and Tobias Engel

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Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia., Christine M. Shortt, Anne Fredsted, Han Bing Chow, Robert Williams, J Richard Skelly, Deirdre Edge, Aidan Bradford, and Ken D. O'Halloran

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Validation of an imageable surgical resection animal model of Glioblastoma (GBM)., Kieron J. Sweeney, Monika A. Jarzabek, Patrick Dicker, Donncha F. O'Brien, John J. Callanan, Annette Byrne, and Jochen HM Prehn

Submissions from 2013

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AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1., Ujval Anilkumar, Petronela Weisová, Heiko Düssmann, Caoimhín G. Concannon, Hans-Georg König, and Jochen HM Prehn

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Paracrine control of tissue regeneration and cell proliferation by Caspase-3., Karen Boland, Lorna Flanagan, and Jochen HM Prehn

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Transcranial magnetic stimulation--a potential unobtrusive, non-invasive and drug-free treatment for obstructive sleep apnoea., Aidan Bradford

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Obstructive Sleep Apnoea, Intermittent Hypoxia and Respiratory Muscle Structure and Function, Aidan Bradford and Ken D. O'Halloran

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Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo., Gary P. Brennan, Eva M. Jimenez-Mateos, Ross C. McKiernan, Tobias Engel, Guri Tzivion, and David C. Henshall

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Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice., Mark Dunleavy, Giovanni Provenzano, David C. Henshall, and Yuri Bozzi