Date of Award
PhD (Doctor of Philosophy)
Dr Mauro Adamo
Dr Francesco Fini
Chemistry, Pharmaceutical, Oxazines
The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity.
In Chapter 2 the synthesis of cycloadducts 2.24 was attempted starting fiom acyl nitroso species 2.2.
In Chapter 3 a novel route to alkene-functionalised monobactams was developed and their potential in diversity oriented synthesis is still in progress.
In Chapter 4 we have described a good enantioselective Michael-initiated ring closure (MIRC) reaction of 2,3 -substituted- 1,1 -cyclopropanediesters under operationally simple conditions and mild PTC catalysis. The study delivers a class of novel enantiopure Michael adducts which could serve as valuable building blocks and as templates of high potential synthetic utility.
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Piras L. Towards the Asymmetric Synthesis of 1,2-Oxazines [PhD Thesis]. Dublin: Royal College of Surgeons in Ireland; 2010