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Theses/Dissertations from 2018

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The Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy, Mariana Alves

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Effects of Service Integration on Utilisation, Coverage and Workload - A Ugandan Case Study of the Integration of Prevention of Mother to Child Transmission of HIV and Maternal, Neonatal and Child Health Related Services, Anna Awor

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Nanoparticles Used in Drug Delivery and Targeting: Understanding the Relationships Between Nanoparticle Quality and Interaction With Platelets, Rana Bakhaidar

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Advancing the Use of Ethics in Community-Based Commercial Drug Formulary Decision-Making: A Critical Analysis Focused on Pharmacy Benefits Coverage Provided by Large Employers in the U.S. Healthcare System, Roy Bentley

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Integrative analysis of the SRC-1 transcriptional networks promoting endocrine resistance in breast cancer, Alacoque L. Browne

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Politics & Policy Processes of Global Health Partnerships: The Case of Gavi, the Vaccine Alliance, Carlos Bruen

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Evidence for a Role for Coagulase-Negative Staphylococci and their Biofilms in the Historic and Future Evolution of Staphylococcus Aureus Including MRSA, Paulo Eduardo Budri

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Smoking and Smoking Cessation in those with Mental Health Difficulties in Ireland, Annette Burns

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The Identification and Characterisation of Genetic Signals of Selection in High Altitude Populations, Amy Cole

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Uncovering a Novel Regulation of Human Epidermal Growth Factor Receptor Signalling by Junctional Adhesion Molecule-A in Breast Cancer, Rodrigo Cruz

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Development of Phase Transfer Catalysed Amidation and Cyclisation Reactions, Dario Destro

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Pharmacoepidemiology of Antihypertensive Medication Adherence in Older Adults and Feasibility of Intervening in Community Pharmacy, Paul Dillon

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ADAM22 as a predictive marker for endocrine resistant metastatic breast cancer and an LGI1 mimetic as a companion therapeutic, Ben Doherty

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The Role of Glycosylated Alpha-1 Antitrypsin in Resolution of Inflammation, Danielle Dunlea

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The Role of the Deubiquitinase USP11 in Endocrine-Driven Breast Cancer, Lisa Dwane

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Tissue-Engineered Vascular Grafts: Recellularisation and Surface Functionalisation with Hybrid Magnetic Nanomedicine Developed with Theranostic Potential, Tatiane Eufrásio da Silva

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The Beneficial Pleiotropic Role of Tumour Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) in Cardiovascular Disease, Hannah Forde

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Development of Functionalised Hydrogels to Enhance Stem Cell Delivery and Integration into the Ischaemic Myocardium, Laura Gallagher

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Surgical Education: Competitive Factors and Platforms to Trainee Progression and Skill Acquisition, Cuan Harrington

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The POSAMINO Study: Development and Validation of Explicit Criteria for Potentially Serious Alcohol Medication Interactions in Older Adults, Alice Holton

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Task Shifting and its Effects on Health Surveillance Assistants in Malawi, John Kadzandira

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Development of a 3D Model of Bone Infection Using Collagen Based Scaffolds to Develop Novel Treatment Strategies for Staphylococcus Aureus Induced Osteomyelitis, Nicola Kavanagh

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The Development of Metallohydroxamates as Novel Anti-Bacterial and Anti-Leishmanial Agents, Donal Keogan

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Functionalisation of Platinum Based Drugs Through Click Chemistry Strategies, Eolann Kitteringham

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Advanced Scaffold-Based Therapeutics for Peripheral Nerve Repair, William Arthur Lackington

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Molecular Patterns underlying TRAIL sensitisation by IAP antagonist TL32711 in Glioblastoma, Frank A. Lincoln

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The assessment of maternal haemodynamic profile via transthoracic bioreactance as a screening tool for the early prediction of preeclampsia (PE) and normotensive fetal growth restriction (FGR)., Cathy Monteith

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The role of the anorectic neuropeptide CART in breast cancer, Brian Mooney

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Development of Novel Hydrogels for Application in Therapeutic Delivery, Robert D. Murphy

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An Investigation of the Neurobiology of Psychogenic Non-Epileptic Seizures, Finian O'Brien

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Development of Inhaled Anti-Tubercular Therapies Using Bioactive Carriers, Gemma O'Connor

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Investigation of the Functional Roles of Calcium Channels, Inflammatory Cytokines and Tumour Micro-Environmental Factors in a Human In Vitro Model of Breast Cancer Calcification, Shane O'Grady

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Electrospinning and electrospraying of unsaturated poly(macrolatone)s: alternative material for biomedical applications., Fernando Cabral Sales de Oliveira

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The Development of Hydrogels and Nanoparticles for Drug and Cell Delivery to the Distal Airways, Christina Payne

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Aldosterone regulation of protein kinase D and sodium reabsorption in the renal cortical collecting duct, Sinéad Quinn

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Could Extracellular microRNAs act as a novel biomarkers of temporal lobe epilepsy?, Rana Raoof

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Development of a Chemoablative, Thermoresponsive Hydrogel as a Drug Delivery Platform for Lung Cancer Applications, Seóna Rossi

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Multimorbidity: the impact of physical activity and physical function on risk and outcomes, Áine Ryan

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The Evaluation of a Pressure Ulcer Prevention Programme (SPUPP) for Older Persons at Risk of Pressure Ulceration, Living in the Community Setting, Emer Shanley

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Investigating biomaterial-based biophysical cues for modulating macrophage polarization towards bone regeneration applications, Rukmani Sridharan

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The Evaluation of Star-Shaped Polypeptides for Gene Delivery in Tissue Engineering, David Walsh

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Targeting Aberrant Transcription in Invasive Lobular Carcinoma Breast Cancer, Louise Walsh

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SRC-1 Mediates DNA Methylation Driving a De-Differentiated State in Endocrine Resistant Breast Cancer by Recruiting a Methyl Regulatory Complex, Elspeth Ward

Theses/Dissertations from 2017

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HOXC11 impacts steroidal adaptability in aromatase inhibitor resistance by up-regulating the androgen receptor, Azlena Ali Beegan

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Cardiovascular and temperature actions of cathinones, Hadeel A. Alsufyani

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3.0 Tesla MRI analysis of the Intra-Uterine Growth Restricted Infant Brain - Comparison of Infants with Normal and Abnormal Antenatal Doppler's., Michael A. Boyle

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Preparation of cyclopentyl derivatives and their application to the synthesis of Active Pharmaceutical Ingredients and Peptide Nucleic Acids, Martina Costanzo

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The role of carer stress in acute and long-term care utilisation by community-dwelling older people, Nora-Ann Donnelly

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Why is blood group a risk marker for myocardial infarction?, Eimear Dunne

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Mechanisms of Crosstalk between JAM-A and HER2 driving Breast Cancer, Astrid Olivia Leech

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BCL2 family proteins interactions as prognostic marker and determinants of therapy responses in breast cancer, Federico Lucantoni

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Feasibility analysis of emergency department key performance indicators in Ireland, Aileen M. McCabe

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Quality of End-of-Life Care in Acute and Community Hospitals from Relatives' Perspectives and Stakeholder Perceptions of the Potential of their Views to Inform Positive Change in Care, Siobhan E. McCarthy

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Novel Strategies to Enhance the Activity of Platinum Drugs Against Colorectal Cancer, Aoife M. McKeon

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MiRNA-124-3p Reduces Cell Viability in Cisplatin Resistant Neuroblastoma Cell Models., John Christopher Nolan

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Anti-angiogenic efficacy of Bevacizumab alone and in combination with a dual PI3K/mTOR inhibitor in an orthotopic model of malignant glioma: A multimodal neuro-imaging approach, Philip J. O'Halloran

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Tackling neuroblastoma: Development of PNA-based miR-34a mimics, Valerio Piacenti

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A Quantitative Study of Hunter-Schreger Brands in the Tooth Enamel of Camelus Dromedarius, Ameera Radhi

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Medication Reconciliation: the primary secondary care interface, Patrick Redmond

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The Importance of Inhaler Technique in Measuring and Calculating Inhaler Adherence, and its Clinical Outcomes, Imran Sulaiman

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Characterisation of angiogenin mediated paracrine neuroprotection in in vitro models, Sergej Susdalzew

Theses/Dissertations from 2016

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The Development of a Fibrin-Collagen-Glycosaminoglycan Scaffold for Heart Valve Tissue Engineering, Claire M. Brougham

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An Electronic Evidence Base Supporting Derivation, Dissemination and Learning for Diagnostic Clinical Prediction Rules in Primary Care Practice, Derek T. Corrigan

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The role of PI3K and ERBB family gene mutations and other abnormalities in resistance to HER2-targeted therapies in HER2-positive breast cancer, Naomi Elster

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Type 2 diabetes and breast cancer - the role of hyperinsulinaemia in breast cancer development and mortality, Emily Jane Gallagher

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Dysregulation of cytokine and monocyte function in systemic lupus erythematosus, Eoghan M. McCarthy

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Trespassing the defensive lines cardiovascular infection, Cormac J. McDonnell

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Multi-functional Copper(II) Drug Candidates as Potential Anti-Cancer Agents, Tadhg James Patrick Mc Givern

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Preparation of polychlorinated isoxazoles and application to organic synthesis, Claudio Monasterolo

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Pharmacoepidemiology and economic evaluation of measures of potentially inappropriate prescribing, Frank Moriarty

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Platelet Biology in Utero-placental Disease, Sieglinde M. Mullers

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To characterize standard laboratory coagulation parameters and plasma thrombin generation in very preterm infants and to investigate their relationship to clinical outcomes, Elaine Neary

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The influence of novel alpha-1 antitrypsin protein binding partners on inflammation and the clinical phenotype in alpha-1 antitrypsin deficiency, Michael E. O'Brien

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Exploring Choice, Home and Health Service Utilisation For People Ageing With An Intellectual Disability During A Time Of Housing Relocation And Transition, Mary-Ann O'Donovan

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The Development of Bilayered Collagen-GAG Scaffolds for Applications in Airway Modelling and Tissue Regeneration, Cian O'Leary

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Natural Honey to Eradicate Nasal Methicillin resistant Staphylococcus aureus (MRSA) A Randomised Control Trial, Toney Thomas Poovelikunnel

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Collagen and Elastin based Tissue Engineered Vascular Grafts, Alan J. Ryan

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Factors Influencing the High School Students' Choice of a Nursing Career in Bahrain: Development of a Best Practice Model for Nursing Recruitment, Eman A. Tawash

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Stereoselective Synthesis of Enantiopure Abasic Nucleosides and 4-Nitroisoxazoles, Federica Torri

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Multi-Functional Metallodrug Candidates as Anti-Cancer Chemotherapeutics, Ziga Ude

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Predicting adverse health outcomes in older community-dwelling adults: a prospective cohort study, Emma Wallace

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Power, culture and researcher identity: an ethos of international academic 'north-south' public health research, Aisling Walsh

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An Exploration Of Falls-Risk After Stroke: A Mixed Methods Approach, Mary Elizabeth Walsh

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Preclinical evaluation of apoptosis resensitisation with Inhibitor-of-apoptosis-protein (IAP) antagonist in glioblastoma cell lines and in an orthotopic mouse GBM model, Zaitun Zakaria

Theses/Dissertations from 2015

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Characterization of a protein: protein interaction between RNF181 and the platelet integrin, αIIbβ3, Seamus Allen

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The Dynamic Platelet Function Assay (DPFA): Assessment of platelet translocation behaviour on von Willebrand Factor (VWF) in pregnancy, neonates and adults, Jonathan James Cowman

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Novel Host Defence Peptide Prodrugs for use in Cystic Fibrosis, Éanna Forde

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Investigation of existing and novel therapeutics to treat intravascular catheter-related infections caused by staphylococci using a combination of in vitro and animal models, Siobhan Hogan

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Expression, Function and Targeting of the ATP-gated P2X7 receptor in epilepsy, Alba Jimenez Pacheco

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The Role of Bid as a positive regulator of mutant SOD1 - induced TLR4 - NF-ҡB signalling in microglia, Sinéad Kinsella

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Bile acids regulate colonic epithelial barrier function: implications for pathogenesis and therapy of inflammatory bowel disease, Natalia Katarzyna Lajczak

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The Role of Notch Receptors in the Alloimmune Response, Ciara N. Magee

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"I found myself staying" - A case study of the job embeddedness and retention of qualified health workers in rural and remote areas of Uganda, Everd B. Maniple

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Paediatric Non-Invasive Pneumococcal Serotypes, Antimicrobial Susceptibilities and Virulence Factors in the Era of Conjugate Vaccines, Martha McElligott

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Development of a microRNA Delivery Scaffold System for Bone Tissue Engineering, Irene Mencía Castaño

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The microbial quality and the use of sodis to treat harvested rainwater in rural areas of Uganda case study: Makondo-Lwengo Masaka, Rosemary Nalwanga

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Development of Cargo-specific Delivery Systems for the Treatment of Myocardial Infarction, Hugh O'Neill

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Factors influencing GP Referrals to Symptomatic Breast Units in Ireland, Niamh O'Rourke

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Specialized Pro-resolution Mediators in Cystic Fibrosis Lung Disease, Fiona C. Ringholz

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Pathways and Protective Factors: Modelling the Effect of Chronic Conditions on Quality of Life in Midlife and Older Irish Adults, Eithne Sexton