Peer Reviewed

1

Document Type

Contribution to Book

Publication Date

25-9-2019

Keywords

mineralocorticoid receptor, aldosterone, glucocorticoids. steroid receptors, protein modification, phosphorylation, Ubiquitylation, SUMOylation, acetylation

Comments

The original book chapter is available at https://www.intechopen.com/

Abstract

The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that transduces the effects of aldosterone and glucocorticoids in a tissue- and cell type-specific ways. Differential regulation of MR by post-translational modifications (PTMs) has been proposed to play a key role in modulating its function. In addition, modifications of other proteins that physically or functionally interact with MR add an additional layer of regulation to aldosterone or glucocorticoid signaling. In this chapter, we will summarize the main post-translational modifications of MR described so far, discussing their possible implications in the physiological and pathological roles of the receptor. We will also discuss post-translational modulation of other proteins impacting MR function such as heat shock protein 90 or 11ß-hydroxysteroid dehydrogenase type 2.

Disciplines

Medical Molecular Biology | Medical Sciences

Citation

Alvarez de la Rosa D, Serrano-Morillas N. Post-Translational Modification of MR Activity In: Harvey B, Jaisser F, editors. Aldosterone-Mineralocorticoid Receptor - Cell Biology to Translational Medicine: InTechOpen; 2019.

DOI Link

10.5772/intechopen.87227

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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