Peer Reviewed

1

Document Type

Article

Publication Date

1-8-2013

Keywords

Animals, Bile Acids and Salts, Cholic Acids, Cholinergic Neurons, Colon, Epithelial Cells, Organ Culture Techniques, Rats, Receptors, G-Protein-Coupled

Funder/Sponsor

Principal Investigator Award from Science Foundation Ireland to SJK and by NBIP Ireland funded under the Higher Education Authority PRTLI Cycle 4.

Comments

This is the peer reviewed version of the following article: Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11 which has been published in final form at 10.1111/nmo.12148. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Abstract

Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic-induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.

Disciplines

Medical Molecular Biology | Medical Sciences

Citation

Ward JB, Mroz MS, Keely SJ. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterology & Motility. 2013; 25(8):708-11

PubMed ID

23634890

DOI Link

10.1111/nmo.12148

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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