Peer Reviewed

1

Document Type

Article

Publication Date

11-2-2013

Keywords

Cystic fibrosis, airway epithelium, microRNA.

Funder/Sponsor

Health Research Board (Grant No. PhD/2007/11). Science Foundation Ireland (Grant No. 12/TIDA/B2265).

Comments

The original article is available at www.mdpi.com

Abstract

MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit.

Disciplines

Medicine and Health Sciences

Citation

Greene CM. MicroRNA Expression in Cystic Fibrosis Airway Epithelium. Biomolecules. 2013;3(1):157-67.

PubMed ID

24970162

DOI Link

10.3390/biom3010157

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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