Peer Reviewed

1

Document Type

Article

Publication Date

1-12-2012

Keywords

Contraceptives, Oral, Hormonal, Cystic Fibrosis, Estradiol, Estrogen Receptor beta, Female, Humans, Interleukin-8, Menstrual Cycle, Pseudomonas aeruginosa, Respiratory Mucosa, Secretory Leukocyte Peptidase Inhibitor, Up-Regulation

Comments

This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Respiratory Medicine on 9th January 2014 available online: http://www.tandfonline.com/https://doi.org/10.1586/ers.12.59

Abstract

Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, Staphylococcus aureus and/or Pseudomonas aeruginosa. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.

Disciplines

Medicine and Health Sciences

Citation

Chotirmall SH, Greene CM, McElvaney NG. Expert Review of Respiratory Medicine. 2012;6(6):573-5.

PubMed ID

23234443

DOI Link

10.1586/ers.12.59

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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