Peer Reviewed

1

Document Type

Article

Publication Date

1-3-2012

Keywords

Gene Expression Regulation, Gene Targeting, Humans, Immunity, Innate, Inflammation, Lung Diseases, MicroRNAs

Comments

“This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Anti-infective Therapy. On 10th January 2014, available online: http://www.tandfonline.com/ https://doi.org/10.1586/eri.11.175

Abstract

miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.

Disciplines

Medicine and Health Sciences

Citation

Hassan T, McKiernan PJ, McElvaney NG, Cryan SA, Greene CM. Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. Expert Review of Anti-Infect Therapy. 201210(3):359-68.

PubMed ID

22397568

DOI Link

10.1586/eri.11.175

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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