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Acoustics, Adolescent, Adult, Aged, Aged, 80 and over, Automatic Data Processing, Female, Humans, Male, Middle Aged, Nebulizers and Vaporizers, Patient Compliance, Time Factors, Young Adult


Health Research Board in Ireland.


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RATIONALE: Poor adherence to inhaler use can be due to poor temporal and/or technique adherence. Up until now there has been no way of reliably tracking both these factors in everyday inhaler use.

OBJECTIVES: This paper introduces a device developed to create time stamped acoustic recordings of an individual's inhaler use, in which empirical evidence of temporal and technique adherence in inhaler use can be monitored over time. The correlation between clinical outcomes and adherence, as determined by this device, was compared for temporal adherence alone and combined temporal and technique adherence.

FINDINGS: The technology was validated by showing that the doses taken matched the number of audio recordings (r2 = 0.94, p20% of their inhaler events. Repeated training reduced this to 7% of participants (p = 0.03). When time of use was considered, there was no evidence of a relationship between adherence and changes in AQLQ (r2 = 0.2) or PEFR (r2 = 0.2). Combining time and technique the rate of adherence was related to changes in AQLQ (r2 = 0.53, p = 0.01) and PEFR (r2 = 0.29, p = 0.01).

CONCLUSIONS: This study presents a novel method to objectively assess how errors in both time and technique of inhaler use impact on clinical outcomes.

TRIAL REGISTRATION: EudraCT 2011-004149-42.


Medicine and Health Sciences


D'Arcy S, MacHale E, Seheult J, Holmes MS, Hughes C, Sulaiman I, Hyland D, O'Reilly C, Glynn S, Al-Zaabi T, McCourt J, Taylor T, Keane F, Killane I, Reilly RB, Costello RW. A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events. PLoS One. 2014;9(6):e98701

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Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.