Peer Reviewed

1

Document Type

Article

Publication Date

9-11-2017

Keywords

3D facial imaging, Asymmetry, Craniofacial dysmorphology, Geometric morphometrics, Mouse models, Neurodevelopmental disorders, Schizophrenia

Funder/Sponsor

Grant 07/IN.1/B960, Grant 086901/Z/08/Z, Grant VEGA 2/0056/16

Comments

The original article is available at: https://link.springer.com/

Abstract

Purpose of Review: In the context of human developmental conditions, we review the conceptualisation of schizophrenia as a neurodevelopmental disorder, the status of craniofacial dysmorphology as a clinically accessible index of brain dysmorphogenesis, the ability of genetically modified mouse models of craniofacial dysmorphology to inform on the underlying dysmorphogenic process and how geometric morphometric techniques in mutant mice can extend quantitative analysis.

Recent Findings: Mutant mice with disruption of neuregulin-1, a gene associated meta-analytically with risk for schizophrenia, constitute proof-of-concept studies of murine facial dysmorphology in a manner analogous to clinical studies in schizophrenia. Geometric morphometric techniques informed on the topography of facial dysmorphology and identified asymmetry therein.

Summary: Targeted disruption in mice of genes involved in individual components of developmental processes and analysis of resultant facial dysmorphology using geometric morphometrics can inform on mechanisms of dysmorphogenesis at levels of incisiveness not possible in human subjects.

Disciplines

Life Sciences

Citation

Waddington JL, Katina S, O'Tuathaigh CMP, Bowman AW. Current Behavioral Neuroscience Reports. 2017;4(4):322-330

PubMed ID

29201594

DOI Link

10.1007/s40473-017-0136-3

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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Life Sciences Commons

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