Peer Reviewed

1

Document Type

Article

Publication Date

21-11-2016

Keywords

Circadian, BMAL1, Innate Immunity, Metabolism

Funder/Sponsor

This work was funded by a StartingInvestigator Research Grant (SIRG) to AMC from Science Foundation Ireland (13/SIRG/2130)

Comments

This article is also available at http://www.journals.elsevier.com/seminars-in-immunology

Abstract

Molecular clocks allow an organism to track time of day, providing the means to anticipate and respond to the daily changes within the environment. In mammals the molecular clock consists of a network of proteins that form auto-regulatory feedback loops that drive rhythms in physiology and behavior. In recent times the extent to which the molecular clock controls key metabolic and immune pathways has begun to emerge. For example, the main clock protein BMAL1 has been linked to mitochondrial metabolism, mitochondrial dynamics and various host defense pathways. The molecular clock may function to integrate daily metabolic changes driven by feeding-fasting to immune function and output. Understanding how the clock intersects with metabolic pathways within immune cells to affect immune phenotypes will have broad implications for the management of metabolic, inflammatory and infectious diseases.

Disciplines

Life Sciences

Citation

Early JO, Curtis AM. Immunometabolism: Is it under the eye of the clock? Seminars in Immunology. 2016 [Article in Press]

PubMed ID

27884543

DOI Link

DOI: 10.1016/j.smim.2016.10.006

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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