Peer Reviewed

1

Document Type

Article

Publication Date

20-8-2018

Keywords

Circadian Clock, BMAL1, Oxidative Stress, Inflammation, Macrophage.

Funder/Sponsor

Science Foundation Ireland (SFI) Starting Investigator Research Award 13/SIRG/2130. SFI Career Development Award 17/CDA/4688. Wellcome Trust Metabolic Grant 205455.

Comments

The original article is available at http://www.pnas.org

Abstract

A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal that the core molecular clock protein, BMAL1, controls the mRNA expression of

Disciplines

Life Sciences

Citation

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D4, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences of the United States of America. 2018.

PubMed ID

30127006

DOI Link

10.1073/pnas.1800431115

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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Life Sciences Commons

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