Peer Reviewed

1

Document Type

Article

Publication Date

1-4-2018

Keywords

acid–base, brain, electrical synapse, gap junctions, heart

Funder/Sponsor

British Heart Foundation Programme Grants RG/08/016 & RG/15/9/31534, E.P. Abraham Cephalosporin Fund,Nora Eccles Harrison Treadwell Foundation, U.S. National Institutes of Health, National Heart, Lung, and Blood Institute Grant R01 HL63969.m Royal Society Fellowship

Comments

The original article is available at http://www.fasebj.org

Abstract

Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular pH (pH

Disciplines

Life Sciences

Citation

Garciarena CD, Malik A, Swietach P, Moreno AP, Vaughan-Jones RD. Distinct moieties underlie biphasic H(+) gating of connexin43 channels, producing a pH optimum for intercellular communication. FASEB journal. 2018; 32(4):1969-1981

PubMed ID

29183963

DOI Link

10.1096/fj.201700876R

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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Life Sciences Commons

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