Follow

Submissions from 2018

PDF

A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models., Caroline Curtin, John C. Nolan, Ross Conlon, Larissa Deneweth, Ciara Gallagher, Ying J. Tan, Brenton Cavanagh, Ahmad Z. Asraf, Harry Harvey, Suzanne Miller-Delaney, Jason Shohet, Isabella Bray, Fergal O'Brien, Raymond L. Stallings, and Olga Piskareva

PDF

Acquired factor xiii deficiency: An uncommon but easily missed cause of severe bleeding., Helen Fogarty, Mary Byrne, Niamh M. O'Connell, Kevin Ryan, Barry White, James S. O'Donnell, and Michelle Lavin

PDF

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication, Carolina D. Garciarena, Akif Malik, Pawel Swietach, Alonso P Moreno, and Richard D Vaughan-Jones

PDF

Successful kidney transplantation normalizes platelet function, Claire Kennedy, Limy Wong, Donal J. Sexton, Jonathan Cowman, Irene Oglesby, Martin Kenny, Peter J. Conlon, and Dermot Kenny

PDF

A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy., Michelle Lavin, Kevin Ryan, Barry White, Mary Byrne, Niamh M. O'Connell, and James S. O'Donnell

PDF

Optimization Techniques for miRNA Expression in Low Frequency Immune Cell Populations., Victoria G Lyons, Natalie L Payne, and Claire E McCoy

PDF

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients., Mark McCormack, Hongsheng Gui, Andrés Ingason, Doug Speed, Galen E B Wright, Eunice J Zhang, Rodrigo Secolin, Clarissa Yasuda, Maxwell Kwok, Stefan Wolking, Felicitas Becker, Sarah Rau, Andreja Avbersek, Kristin Heggeli, Costin Leu, Chantal Depondt, Graeme J Sills, Anthony G Marson, Pauls Auce, Martin J Brodie, Ben Francis, Michael R Johnson, Bobby P C Koeleman, Pasquale Striano, Antonietta Coppola, Federico Zara, Wolfram S Kunz, Josemir W Sander, Holger Lerche, Karl Martin Klein, Sarah Weckhuysen, Martin Krenn, Lárus J Gudmundsson, Kári Stefánsson, Roland Krause, Neil Shear, Colin J D Ross, Norman Delanty, Munir Pirmohamed, Bruce C Carleton, Fernando Cendes, Iscia Lopes-Cendes, Wei-Ping Liao, Terence J O'Brien, Sanjay M Sisodiya, Stacey Cherny, Patrick Kwan, Larry Baum, and Gianpiero L. Cavalleri

PDF

Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer, Cian M. mcCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vickly L. Katt, Jonathan A. Coulter, Tracy Robson, and Helen O. McCarthy

PDF

miR-222 isoforms are differentially regulated by type-I interferon., Charlotte Nejad, Katherine A Pillman, Katherine J Siddle, Geneviève Pépin, Minna-Liisa Änkö, Claire E McCoy, Traude H Beilharz, Lluís Quintana-Murci, Gregory J Goodall, Cameron P Bracken, and Michael P Gantier

PDF

Switching from abacavir to tenofovir disoproxil fumarate is associated with rises in soluble glycoprotein VI, suggesting changes in platelet-collagen interactions., Jane A O'Halloran, Eimear Dunne, Willard Tinago, Stephanie Denieffe, Dermot Kenny, and Patrick WG Mallon

PDF

BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer, Sarah Shields, Emer Conroy, Tony O'Grady, Alo McGoldrick, Kate Connor, Mark P. Ward, Zivile Useckaite, Eugene Dempsey, Rebecca Reily, Youe Fan, Anthony Chubb, Gomez-Matallanas, Elaine W. Kay, Darran P O'Connor, Amanda McCann, William N. Gallagher, and Judith A. Coppinger

PDF

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study., Christopher D Whelan, Andre Altmann, Juan A. Botía, Neda Jahanshad, Derrek P. Hibar, Julie Absil, Saud Alhusaini, Marina KM Alvim, Pia Auvinen, Emanuele Bartolini, Felipe PG Bergo, Tauana Bernardes, Karen Blackmon, Barbara Braga, Maria Eugenia Caligiuri, Anna Calvo, Sarah J. Carr, Shuai Chen, Andrea Cherubini, Philippe David, Martin Domin, Sonya Foley, Wendy França, Gerrit Haaker, Dmitry Isaev, Simon S. Keller, Raviteja Kotikalapudi, Magdalena A. Kowalczyk, Ruben Kuzniecky, Soenke Langner, Matteo Lenge, Kelly M. Leyden, Min Liu, Richard Q. Loi, Pascal Martin, Mario Mascalchi, Marcia E. Morita, Jose C. Pariente, Raul Rodríguez-Cruces, Christian Rummel, Taavi Saavalainen, Mira K. Semmelroch, Mariasavina Severino, Rhys H. Thomas, Manuela Tondelli, Domenico Tortora, Anna Elisabetta Vaudano, Lucy Vivash, Felix von Podewils, Jan Wagner, Bernd Weber, Yi Yao, Clarissa L. Yasuda, Guohao Zhang, Nuria Bargalló, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris C. Bernhardt, Ingmar Blümcke, Chad Carlson, Gianpiero L. Cavalleri, Fernando Cendes, Luis Concha, Norman Delanty, Chantal Depondt, Orrin Devinsky, Colin P. Doherty, Niels K. Focke, Antonio Gambardella, Renzo Guerrini, Khalid Hamandi, Graeme D. Jackson, Reetta Kälviäinen, Peter Kochunov, Patrick Kwan, Angelo Labate, Carrie R. McDonald, Stefano Meletti, Terence J. O'Brien, Sebastien Ourselin, Mark P. Richardson, Pasquale Striano, Thomas Thesen, Roland Wiest, Junsong Zhang, Annamaria Vezzani, Mina Ryten, Paul M. Thompson, and Sanjay M. Sisodiya

Submissions from 2017

PDF

eHealth as a Facilitator of Precision Medicine in Epilepsy, Gianpiero Cavalleri, Slave Petrovski, Mary Fitzsimons, and Norman Delanty

PDF

Genetic structure in the Sherpa and neighboring Nepalese populations., Amy M. Cole, Sean Cox, Choongwon Jeong, Nayia Petousi, Dhana R. Aryal, Yunden Droma, Masayuki Hanaoka, Masao Ota, Nobumitsu Kobayashi, Paolo Gasparini, Hugh Montgomery, Peter Robbins, Anna Di Rienzo, and Gianpiero L. Cavalleri

PDF

Simultaneous occurrence of nonepileptic and epileptic seizures during a single period of in-patient video-electroencephalographic monitoring, Hany El-Naggar, Patrick Moloney, Peter Widdess-Walsh, Ronan Kilbride, Norman Delanty, and Gerard Mullins

PDF

Genomic insights into the population structure and history of the Irish Travellers., Edmund Gilbert, Shai Carmi, Sean Ennis, James F Wilson, and Gianpiero L. Cavalleri

PDF

The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland, Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Anne M. Molloy, Lawrence C. Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J. Lawson, James F. Wilson, and Gianpiero L. Cavalleri

PDF

Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment., John W McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, and Helen O. McCarthy

PDF

miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis., Claire E McCoy

PDF

Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1, Colm MP O'Tuathaigh, Naina Mathur, Matthew J. O'Callaghan, Lynsey MacIntyre, Richard Harvey, Dona Lai, John L. Waddington, Bemjamom S. Pickard, David D. Watson, and Paula M. Moran

PDF

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies., Colm M P O'Tuathaigh, Paula M Moran, Xuechu C Zhen, and John L. Waddington

PDF

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease., Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke AJ O'Neill, Kingston HG Mills, and Anne M. Curtis

PDF

Discovery of novel heart rate-associated loci using the Exome Chip., Marten E van den Berg, Helen R Warren, Claudia P Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A Bihlmeyer, Yi-Ping Fu, Stefan Weiss, Henry J Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V Smith, Leo-Pekka Lyytikäinen, Leanne M. Hall, Jessica van Setten, Stella Trompet, Bram P Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A Kors, Claudia T Silva, Alvaro Alonso, Joshua C Bis, Rudolf de Boer, Hugoline G de Haan, Renée de Mutsert, George Dedoussis, Anna F Dominiczak, Alex S F Doney, Patrick T Ellinor, Ruben N Eppinga, Stephan B Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B Harris, Susan R Heckbert, Paul L Huang, Shih-Jen Hwang, Mika Kähönen, Jørgen K Kanters, Ivana Kolcic, Lenore J Launer, Man Li, Jie Yao, Allan Linneberg, Simin Liu, Peter W Macfarlane, Massimo Mangino, Andrew D Morris, Antonella Mulas, Alison D Murray, Christopher P Nelson, Marco Orrú, Sandosh Padmanabhan, Annette Peters, David J Porteous, Neil Poulter, Bruce M Psaty, Lihong Qi, Olli T Raitakari, Fernando Rivadeneira, Carolina Roselli, Igor Rudan, Naveed Sattar, Peter Sever, Moritz F Sinner, Elsayed Z Soliman, Timothy D Spector, Alice V. Stanton, Kathleen E Stirrups, Kent D Taylor, Martin D Tobin, André Uitterlinden, Ilonca Vaartjes, Arno W Hoes, Peter van der Meer, Uwe Völker, Melanie Waldenberger, Zhijun Xie, Magdalena Zoledziewska, Andrew Tinker, Ozren Polasek, Jonathan Rosand, Yalda Jamshidi, Cornelia M van Duijn, Eleftheria Zeggini, J Wouter Jukema, Folkert W Asselbergs, Nilesh J Samani, Terho Lehtimäki, Vilmundur Gudnason, James Wilson, Steven A Lubitz, Stefan Kääb, Nona Sotoodehnia, Mark J Caulfield, Colin NA Palmer, Serena Sanna, Dennis O Mook-Kanamori, Panos Deloukas, Oluf Pedersen, Jerome I Rotter, Marcus Dörr, Chris J O'Donnell, Caroline Hayward, Dan E Arking, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H Stricker, and Patricia B Munroe

PDF

Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures., Vicente Villanueva, Martin Holtkamp, Norman Delanty, Juan Rodriguez-Uranga, Rob McMurray, and Patricia Santagueda

PDF

Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the "Prism" of Schizophrenia., John L. Waddington, Stanislav Katina, Colm M. O'Tuathaigh, and Adrian W Bowman

PDF

Modelling the neuromotor abnormalities of psychotic illness: Putative mechanisms and systems dysfunction., John L. Waddington and Colm M. O'Tuathaigh

PDF

Entrapment of Autologous von Willebrand Factor on Polystyrene/Poly(methyl methacrylate) Demixed Surfaces, Johanna Ward, Eimear Dunne, David Bishop, Adrian Boyd, Dermot Kenny, and Brian J. Meenan

PDF

ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis., Guohao Zhang, Peter Kochunov, Elliot Hong, Sinead Kelly, Christopher Whelan, Neda Jahanshad, Paul Thompson, and Jian Chen

Submissions from 2016

PDF

Immunometabolism: Is it under the eye of the clock?, James O. Early and Anne M. Curtis

PDF

Relationship of suicide rates with climate and economic variables in Europe during 2000-2012., Konstantinos N. Fountoulakis, Isaia Chatzikosta, Konstantinos Pastiadis, Prodromos Zanis, Wolfram Kawohl, Ad JFM Kerkhof, Alvydas Navickas, Cyril Höschl, Dusica Lecic-Tosevski, Eliot Sorel, Elmars Rancans, Eva Palova, Georg Juckel, Goran Isacsson, Helena Korosec Jagodic, Ileana Botezat-Antonescu, Janusz Rybakowski, Jean Michel Azorin, John Cookson, John Waddington, Peter Pregelj, Koen Demyttenaere, Luchezar G. Hranov, Lidija Injac Stevovic, Lucas Pezawas, Marc Adida, Maria Luisa Figuera, Miro Jakovljević, Monica Vichi, Giulio Perugi, Ole A. Andreassen, Olivera Vukovic, Paraskevi Mavrogiorgou, Peeter Varnik, Peter Dome, Petr Winkler, Raimo KR Salokangas, Tiina From, Vita Danileviciute, Xenia Gonda, Zoltan Rihmer, Jonas Forsman, Anne Grady, Thomas Hyphantis, Ingrid Dieset, Susan Soendergaard, Maurizio Pompili, and Per Bech

PDF

Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells., G J. Kelly, A Foltyn-Arfa Kia, F Hassan, S O'Grady, Maria P. Morgan, B S. Creaven, S McClean, Judith H. Harmey, and Marc Devocelle

PDF

Inhibition of major integrin αVβ3 reduces Staphylococcus aureus attachment to sheared human endothelial cells., Cormac J. McDonnell, Carolina D. Garciarena, Rebecca L. Watkin, Tony M. McHale, Alisha McLoughlin, Jorien Claes, Peter Verhamme, Philip M. Cummins, and Steven W. Kerrigan

PDF

Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis., Katie Nolan, Franziska Walter, Liam P. Tuffy, Simone Poeschel, Ross Gallagher, Stefan Haunsberger, Isabella Bray, Raymond L. Stallings, Caoimhín G. Concannon, and Jochen HM Prehn

PDF

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3., Callum N. Watson, Steven W. Kerrigan, Dermot Cox, Ian R. Henderson, Steve P. Watson, and Mònica Arman

Submissions from 2015

PDF

Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion., Niamh M. Cooke, Cathy D. Spillane, Orla Sheils, John O'Leary, and Dermot Kenny

PDF

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer., Cameron N. Johnstone, Yvonne E. Smith, Yuan Cao, Allan D. Burrows, Ryan SN Cross, Xiawei Ling, Richard P. Redvers, Judy P. Doherty, Bedrich L. Eckhardt, Anthony L. Natoli, Christina M. Restall, Erin Lucas, Helen B. Pearson, Siddhartha Deb, Kara L. Britt, Alexandra Rizzitelli, Jason Li, Judith H. Harmey, Normand Pouliot, and Robin L. Anderson

Submissions from 2014

PDF

A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function., Róisín Moriarty, Ciara A. McManus, Matthew Lambert, Thea Tilley, Marc Devocelle, Marian Brennan, Steven W. Kerrigan, and Dermot Cox

PDF

Poly(Ethylene glycol)-based backbones with high peptide loading capacities., Aoife O'Connor, Jean-Noel Marsat, Annachiara Mitrugno, Tom Flahive, Niamh Moran, David Brayden, and Marc Devocelle

PDF

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins., Iris Postmus, Stella Trompet, Harshal A Deshmukh, Michael R Barnes, Xiaohui Li, Helen R Warren, Daniel I Chasman, Kaixin Zhou, Benoit J Arsenault, Louise A Donnelly, Kerri L Wiggins, Christy L Avery, Paula Griffin, QiPing Feng, Kent D Taylor, Guo Li, Daniel S Evans, Albert V Smith, Catherine E de Keyser, Andrew D Johnson, Anton J M de Craen, David J Stott, Brendan M Buckley, Ian Ford, Rudi G J Westendorp, P Eline Slagboom, Naveed Sattar, Patricia B Munroe, Peter Sever, Neil Poulter, Alice Stanton, Denis C Shields, Eoin O'Brien, Sue Shaw-Hawkins, Y-D Ida Chen, Deborah A Nickerson, Joshua D Smith, Marie Pierre Dubé, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Paul M McKeigue, John Betteridge, Andrew Neil, Paul N Durrington, Alex Doney, Fiona Carr, Andrew Morris, Mark I McCarthy, Leif Groop, Emma Ahlqvist, Joshua C Bis, Kenneth Rice, Nicholas L Smith, Thomas Lumley, Eric A Whitsel, Til Stürmer, Eric Boerwinkle, Julius S Ngwa, Christopher J O'Donnell, Ramachandran S Vasan, Wei-Qi Wei, Russell A Wilke, Ching-Ti Liu, Fangui Sun, Xiuqing Guo, Susan R Heckbert, Wendy Post, Nona Sotoodehnia, Alice M Arnold, Jeanette M Stafford, Jingzhong Ding, David M Herrington, Stephen B Kritchevsky, Gudny Eiriksdottir, Leonore J Launer, Tamara B Harris, Audrey Y Chu, Franco Giulianini, Jean G MacFadyen, Bryan J Barratt, Fredrik Nyberg, Bruno H Stricker, André G Uitterlinden, Albert Hofman, Fernando Rivadeneira, Valur Emilsson, Oscar H Franco, Paul M Ridker, Vilmundur Gudnason, Yongmei Liu, Joshua C Denny, Christie M Ballantyne, Jerome I Rotter, L Adrienne Cupples, Bruce M Psaty, Colin N A Palmer, Jean-Claude Tardif, Helen M Colhoun, Graham Hitman, Ronald M Krauss, J Wouter Jukema, and Mark J Caulfield

PDF

TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems., Claire Wynne, Elisa Lazzari, Siobhán Smith, Eoghan M. McCarthy, Joan Ní Gabhann, Lara E. Kallal, Rowan Higgs, Sally-Ann Cryan, Christine A. Biron, and Caroline A. Jefferies

PDF

Follow-up of blood-pressure lowering and glucose control in type 2 diabetes., Sophia Zoungas, John Chalmers, Bruce Neal, Laurent Billot, Qiang Li, Yoichiro Hirakawa, Hisatomi Arima, Helen Monaghan, Rohina Joshi, Stephen Colagiuri, Mark E Cooper, Paul Glasziou, Diederick Grobbee, Pavel Hamet, Stephen Harrap, Simon Heller, Liu Lisheng, Giuseppe Mancia, Michel Marre, David R Matthews, Carl E Mogensen, Vlado Perkovic, Neil Poulter, Anthony Rodgers, Bryan Williams, Stephen MacMahon, Anushka Patel, Mark Woodward, ADVANCE-ON, and Alice Stanton

Submissions from 2013

PDF

The Role of Platelets in Viral Hemorrhagic Fevers, Dermot Cox, Maria S. Salvato, and Juan Carlos Zapata

PDF

MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1., Laura Creevey, Jacqueline Ryan, Harry Harvey, Isabella M. Bray, Maria Meehan, Adnan R. Khan, and Raymond L. Stallings

PDF

Recurring themes arising during medical research ethics committee review., Eoin Kelleher, Alice Stanton, Gillian Vale, and David Smith

PDF

Platelet-bacterial interactions in the pathogenesis of infective endocarditis. Part II: The Staphylococcus, Steven W. Kerrigan

PDF

Increased platelet counts and platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study, J A. Kinsella, W O. Tobin, S Tierney, T M. Feeley, B Egan, D R. Collins, T Coughlan, D O'Neill, J Harbison, P Madhavan, D J. Moore, S M. O'Neill, M P. Coughlan, C P. Doherty, R P. Murphy, M Saqqur, Niamh Moran, G Hamilton, and D JH McCabe

PDF

A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity., James P. Parker, Hassan Nimir, Darren M. Griffith, Brian Duff, Anthony J. Chubb, Marian P. Brennan, Maria Morgan, Denise Egan, and Celine Marmion

PDF

Pregnancy-Specific Glycoproteins Bind Integrin αIIbβ3 and Inhibit the Platelet-Fibrinogen Interaction., Daniel K. Shanley, Patrick K. Kiely, Kalyan Golla, Seamus Allen, Kenneth Martin, Ronan T. O'Riordan, Melanie Ball, John D. Aplin, Bernhard B. Singer, Noel Caplice, Niamh Moran, and Tom Moore

PDF

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases., Arthur Smardencas, Kerelos Rizkalla, Hyun Ah Kim, Jim Massalas, Claire O'Leary, Michelle E. Ehrlich, Günter Schütz, Andrew J. Lawrence, and John Drago

PDF

Platelet-bacterial interactions in the pathogenesis of infective endocarditis. Part I: The Streptococcus, Dorothea Tilley and Steven W. Kerrigan

PDF

Expressional alterations in functional ultra-conserved non-coding rnas in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells., Karen M. Watters, Kenneth Bryan, Niamh H. Foley, Maria Meehan, and Raymond L. Stallings

Submissions from 2012

PDF

Chronic Adolescent Exposure to Delta-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Indices of Dopaminergic, Endocannabinoid and GABAergic Pathways., Aine T. Behan, Magdalena Hryniewiecka, Colm MP O'Tuathaigh, Anthony Kinsella, Mary Cannon, Maria Karayiorgou, Joseph A. Gogos, John L. Waddington, and David R. Cotter

PDF

Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation., Rachel F. Cox, Aron Hernandez-Santana, S Ramdass, Gillian McMahon, Judith H. Harmey, and Maria P. Morgan

PDF

Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment., Rachel F. Cox, Allan Jenkinson, Kerstin Pohl, Fergal O'Brien, and Maria P. Morgan

PDF

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers., Anneleen Decock, Maté Ongenaert, Jasmien Hoebeeck, Katleen De Preter, Gert Van Peer, Wim Van Criekinge, Ruth Ladenstein, Johannes H. Schulte, Rosa Noguera, Raymond L. Stallings, An Van Damme, Geneviève Laureys, Joëlle Vermeulen, Tom Van Maerken, Frank Speleman, and Jo Vandesompele

PDF

Platelet-Bacterial Interactions as Therapeutic Targets in Infective Endocarditis, Steven W. Kerrigan and Dermot Cox

PDF

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis., Ross C. McKiernan, Eva M. Jimenez-Mateos, Isabella Bray, Tobias Engel, Gary P. Brennan, Takanori Sano, Zuzanna Michalak, Catherine Moran, Norman Delanty, Michael Farrell, Donncha O'Brien, Robert Meller, Roger P. Simon, Raymond L. Stallings, and David C. Henshall

PDF

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene., Maria Meehan, Laavanya Parthasarathi, Niamh Moran, Caroline A. Jefferies, Niamh Foley, Elisa Lazzari, Derek Murphy, Jacqueline Ryan, Berenice Ortiz, Armida WM Fabius, Timothy A. Chan, and Raymond L. Stallings

PDF

Differential DNA methylation patterns define status epilepticus and epileptic tolerance., Suzanne F C Miller-Delaney, Sudipto Das, Takanori Sano, Eva M. Jimenez-Mateos, Kenneth Bryan, Patrick G. Buckley, Raymond L. Stallings, and David C. Henshall

PDF

Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase., Erika Salvi, Zoltán Kutalik, Nicola Glorioso, Paola Benaglio, Francesca Frau, Tatiana Kuznetsova, Hisatomi Arima, Clive Hoggart, Jean Tichet, Yury P. Nikitin, Costanza Conti, Jitka Seidlerova, Valérie Tikhonoff, Katarzyna Stolarz-Skrzypek, Toby Johnson, Nabila Devos, Laura Zagato, Simonetta Guarrera, Roberta Zaninello, Andrea Calabria, Benedetta Stancanelli, Chiara Troffa, Lutgarde Thijs, Federica Rizzi, Galina Simonova, Sara Lupoli, Giuseppe Argiolas, Daniele Braga, Maria C. D'Alessio, Maria F. Ortu, Fulvio Ricceri, Maurizio Mercurio, Patrick Descombes, Maurizio Marconi, John Chalmers, Stephen Harrap, Jan Filipovsky, Murielle Bochud, Licia Iacoviello, Justine Ellis, Alice V. Stanton, Maris Laan, Sandosh Padmanabhan, Anna F. Dominiczak, Nilesh J. Samani, Olle Melander, Xavier Jeunemaitre, Paolo Manunta, Amnon Shabo, Paolo Vineis, Francesco P. Cappuccio, Mark J. Caulfield, Giuseppe Matullo, Carlo Rivolta, Patricia B. Munroe, Cristina Barlassina, Jan A. Staessen, Jacques S Beckmann, and Daniele Cusi

PDF

Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus., Siobhán Smith, Joan Nı Gabhann, Rowan Higgs, Kevin Stacey, Marie Wahren-Herlenius, Alexander Espinosa, Maria Grazia Totaro, Antonio Sica, Elizabeth Ball, Aubrey Bell, James Johnston, Peter Browne, Lorraine O'Neill, Grainne Kearns, and Caroline A. Jefferies

PDF

Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity., Kevin B. Stacey, Eamon Breen, and Caroline A. Jefferies

PDF

Barriers to the uptake of evidence from systematic reviews and meta-analyses: a systematic review of decision makers' perceptions., John Wallace, Bosah Nwosu, and Mike Clarke

PDF

Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis., Amro Widaa, Tania Claro, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

Submissions from 2011

PDF

Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis., Tania Claro, Amro Widaa, Maghnus O'Seaghdha, Helen Miajlovic, Timothy J. Foster, Fergal J. O'Brien, and Steven W. Kerrigan

PDF

Evaluation and optimization of IgY spin column technology in the depletion of abundant proteins from human serum., Laura Corrigan, Caroline Jefferies, T Clive Lee, and Jacqueline Daly

PDF

Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation., Dermot Cox, Steven W. Kerrigan, and Steve Watson

PDF

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens., Stephane Desgranges, Florie Le Prieult, Alan Daly, Marian Brennan, Dilip K. Rai, Anusha P. Subasinghage, Chandralal M. Hewage, Sally-Ann Cryan, Catherine M. Greene, Noel G. McElvaney, Timothy P. Smyth, Deirdre Fitzgerald-Hughes, Hilary Humphreys, and Marc Devocelle

PDF

TIN-a combinatorial compound collection of synthetically feasible multicomponent synthesis products., Kristl V. Dorschner, David Toomey, Marian P. Brennan, Tim Heinemann, Fergal J. Duffy, Kevin B. Nolan, Dermot Cox, Mauro FA Adamo, and Anthony J. Chubb

PDF

Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus., Giuseppe Gangarossa, Manuela Di Benedetto, Gerard J. O'Sullivan, Mark Dunleavy, Cristina Alcacer, Alessandra Bonito-Oliva, David C. Henshall, John L. Waddington, Emmanuel Valjent, and Gilberto Fisone

PDF

Simultaneous release of a hydroxy-methylglutaryl coenzyme A reductase inhibitor and a glycoprotein IIb/IIIa antagonist from a thermoresponsive NiPAAm/NtBAAm copolymer system., Jennifer A. Hickey, I Lynch, Kenneth A. Dawson, Dermot Cox, and A K. Keenan

PDF

Platelet signalling networks: pathways perturbation demonstrates differential sensitivity of ADP secretion and fibinogen binding., Federica Lombardi, Ciaran De Chaumont, Denis C. Shields, and Niamh Moran

PDF

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans., Mark McCormack, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, Dalia Kasperavičiūtė, Mary Carrington, Graeme J. Sills, Tony Marson, Xiaoming Jia, Paul IW de Bakker, Krishna Chinthapalli, Mariam Molokhia, Michael R. Johnson, Gerard D. O'Connor, Elijah Chaila, Saud Alhusaini, Kevin V. Shianna, Rodney A. Radtke, Erin L. Heinzen, Nicole Walley, Massimo Pandolfo, Werner Pichler, B Kevin Park, Chantal Depondt, Sanjay M. Sisodiya, David B. Goldstein, Panos Deloukas, Norman Delanty, Gianpiero L. Cavalleri, and Munir Pirmohamed

PDF

Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology., Annette E. Rünker, Colm O'Tuathaigh, Mark Dunleavy, Derek W. Morris, Graham E. Little, Aiden P. Corvin, Michael Gill, David C. Henshall, John L. Waddington, and Kevin J. Mitchell

PDF

A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project., Ciara Vangjeli, Patrick Dicker, David-Alexandre Tregouet, Denis C. Shields, Alun Evans, and Alice V. Stanton

Submissions from 2010

PDF

TNF Receptor-Associated Factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets., J F. Arthur, Y Shen, E E. Gardiner, Lorraine Coleman, Dermot Kenny, R K. Andrews, and Michael C. Berndt

PDF

Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders, Cynthia M. Beall, Gianpiero L. Cavalleri, Libin Deng, Robert C. Elston, Yang Gao, Jo Knight, Chaohua Li, Jiang Chuan Li, Yu Liang, Mark McCormack, Hugh E. Montgomery, Hao Pan, Peter A. Robbins, Kevin V. Shianna, Siu Cheung Tam, Ngodup Tsering, Krishna Veeramah, Wei Wang, Puchung Wangdui, Michael E. Weale, Yaomin Xu, Zhe Xu, Ling Yang, M Justin Zaman, Changqing Zeng, Li Zhang, Xianglong Zhang, Pingcuo Zhaxi, and Yong Tang Zheng

PDF

Integrins as therapeutic targets: lessons and opportunities., Dermot Cox, Marian P. Brennan, and Niamh Moran

PDF

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors., Rowan Higgs, Elisa Lazzari, Claire Wynne, Joan Ní Gabhann, Alexander Espinosa, Marie Wahren-Herlenius, and Caroline A. Jefferies

PDF

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer, Gregor Kijanka, Suzanne Hector, Elaine W. Kay, Frank E. Murray, Robert Cummins, Derek Murphy, B MacCraith, Jochen HM Prehn, and Dermot Kenny

PDF

The meniscus, calcification and osteoarthritis: a pathologic team., Paul A. MacMullan and Geraldine M. McCarthy

PDF

Clopidogrel discontinuation and platelet reactivity following coronary stenting., Darren Mylotte, Aaron Peace, Tony Tedesco, Fabio Mangiacapra, Patrick Dicker, Dermot Kenny, and David Foley

PDF

Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa., Helen J. Petersen, Ciara Keane, Howard F. Jenkinson, M Margaret Vickerman, Amy Jesionowski, Janet C. Waterhouse, Dermot Cox, and Steven W. Kerrigan

PDF

Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function., Soumya Raychaudhuri, Joshua M. Korn, Steven A A. McCarroll, The International Schizophrenia Consortium, David Altshuler, Pamela Sklar, Shaun Purcell, and Mark J. Daly

PDF

Prevalence and clinical correlates of depression in the acute phase of first episode schizophrenia, Eric Roche, Mary Clarke, Stephen Browne, Niall Turner, Orflaith McTuige, Moaayad Kamali, Anthony Kinsella, Conall Larkin, John L. Waddington, and Eadbhard O'Callaghan

PDF

Genome wide association study of nonsynonymous Single Nucleotide Polymorphisms for seven common diseases, Praveen Surendran, Alice Stanton, and Denis Shields

Submissions from 2009

PDF

Elucidating the role of Staphylococcus epidermidis serine-aspartate repeat protein G in platelet activation., Marian P. Brennan, A Loughman, Marc Devocelle, S Arasu, Anthony J. Chubb, T J. Foster, and Dermot Cox

PDF

Continuous positive airway pressure and platelet activation in obstructive sleep apnoea., Dermot Cox and Aidan Bradford

PDF

Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer., Glen A. Doherty, Sinead M. Byrne, Eamonn S. Molloy, Vikrum Malhotra, Sandra C. Austin, Elaine W. Kay, Frank E. Murray, and Desmond J. Fitzgerald

PDF

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway., Alexander Espinosa, Valerie Dardalhon, Susanna Brauner, Aurelie Ambrosi, Rowan Higgs, Fransisco J. Quintana, Maria Sjöstrand, Maija-Leena Eloranta, Joan Ní Gabhann, Ola Winqvist, Birgitta Sundelin, Caroline A. Jefferies, Björn Rozell, Vijay K. Kuchroo, and Marie Wahren-Herlenius

PDF

A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity., Darren Griffith, Maria P. Morgan, and Celine J. Marmion

PDF

cDNA amplification by SMART-PCR and suppression subtractive hybridization (SSH)-PCR., Andrew Hillmann, Eimear Dunne, and Dermot Kenny

PDF

The thrombotic potential of oral pathogens., Steven W. Kerrigan and Dermot Cox

PDF

Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer., Anthony J. Ryan, Silvia Napoletano, Paul A. Fitzpatrick, Caroline A. Currid, Niamh C. O'Sullivan, and Judith H. Harmey

PDF

Genomes2Drugs: identifies target proteins and lead drugs from proteome data, David Toomey, Heinrich C. Hoppe, Marian P. Brennan, Kevin B. Nolan, and Anthony J. Chubb

Submissions from 2008

PDF

C-reactive protein binds to alphaIIbbeta3., Marian P. Brennan, Roisin D. Moriarty, S Grennan, Anthony J. Chubb, and Dermot Cox

PDF

Targeting IRFs by ubiquitination: regulating antiviral responses., Rowan Higgs and Caroline A. Jefferies

PDF

Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro., Steven W. Kerrigan, Niamh Clarke, Anthony Loughman, Gerardene Meade, Timothy J. Foster, and Dermot Cox

PDF

Marked variation in predicted and observed variability of tandem repeat loci across the human genome., Colm T. O'Dushlaine and Denis C. Shields

PDF

Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus., Heidi O'Neill, Janne Lebeck, Patrick B. Collins, Tae-Hwan Kwon, Jørgen Frøkiaer, and Søren Nielsen