Peer Reviewed
1
Document Type
Article
Publication Date
25-2-2015
Keywords
Bone Graft Substitute, Collagen-Based Scaffolds, Equine, Tissue Engineering, Mandibular Aneurysmal Bone Cyst, Computed Tomography
Funder/Sponsor
The cost associated with the management of this clinical case has been equally supported by the horse’s owner and University College Dublin Veterinary Hospital. Funding has also been provided by Enterprise Ireland Commercialisation Fund Technology Development Award (CFTD/2009/0104) and some financial support for additional follow-up imaging (<€1000) was provided by SurgaColl Technologies Limited.
Abstract
An unmet need remains for a bone graft substitute material that is biocompatible, biodegradable and capable of promoting osteogenesis safely in vivo. The aim of this study was to investigate the use of a novel collagen-hydroxyapatite (CHA) bone graft substitute in the clinical treatment of a mandibular bone cyst in a young horse and to assess its potential to enhance repair of the affected bone. A 2 year-old thoroughbred filly, presenting with a multilobulated aneurysmal bone cyst, was treated using the CHA scaffold. Post-operative clinical follow-up was carried out at 2 weeks and 3, 6 and 14 months. Cortical thickening in the affected area was observed from computed tomography (CT) examination as early as 3 months post-surgery. At 14 months, reduced enlargement of the operated mandible was observed, with no fluid-filled area. The expansile cavity was occupied by moderately dense mineralized tissue and fat and the compact bone was remodelled, with a clearer definition between cortex and medulla observed. This report demonstrates the promotion of enhanced bone repair following application of the CHA scaffold material in this craniomaxillofacial indication, and thus the potential of this material for translation to human applications. Copyright © 2015 John Wiley & Sons, Ltd.
Disciplines
Anatomy
Citation
David F, Levingstone TJ, Schneeweiss W, de Swarte M, Jahns H, Gleeson JP, O'Brien FJ. Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly. Journal of Tissue Engineering & Regenerative Medicine. 2015; Wiley Online Library.
PubMed ID
25712436
Link to this item at
http://epubs.rcsi.ie/anatart/71/
DOI Link
10.1002/term.2006
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Comments
This article is also available at http://onlinelibrary.wiley.com/doi/10.1002/term.2006/epdf