Renin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease Progression.

Chuan Kai Hian, Royal College of Surgeons in Ireland-Perdana University
Chin Liang Lee, Royal College of Surgeons in Ireland-Perdana University
Warren Thomas, Royal College of Surgeons in Ireland-Perdana University

This is the peer-reviewed but unedited manuscript version of the following article: Hian CK, Thomas W. Renin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease Progression. Nephron. 2016;134(2):59-63. (DOI: 10.1159/000448296) The final, published version is available at http://www.karger.com/?DOI: 10.1159/000448296

Abstract

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease characterised by the formation of multiple renal cysts that adversely affect renal function. ADPKD shows significant progression with age when complications due to hypertension are most significant. The activation of the renin-angiotensin-aldosterone system (RAAS) occurs in progressive kidney disease leading to hypertension. The RAAS system may also contribute to ADPKD progression by stimulating signalling pathways in the renal cyst cells to promote growth and deregulate epithelial transport. This mini review focuses on the contribution of the RAAS system to renal cyst enlargement and the potential for antagonists of the RAAS system to suppress cyst enlargement as well as control ADPKD-associated hypertension.