Peer Reviewed

1

Document Type

Article

Publication Date

1-7-2016

Keywords

Adjunctive Therapy, Ant-Tubercular, Immunomodulation, Inhalation, Particle Engineering, Pre-Clinical Testing, Targeted Drug Delivery, Vitamin

Abstract

Centuries since it was first described, tuberculosis (TB) remains a significant global public health issue. Despite ongoing holistic measures implemented by health authorities and a number of new oral treatments reaching the market, there is still a need for an advanced, efficient TB treatment. An adjunctive, host-directed therapy designed to enhance endogenous pathways and hence compliment current regimens could be the answer. The integration of drug repurposing, including synthetic and naturally occurring compounds, with a targeted drug delivery platform is an attractive development option. In order for a new anti-tubercular treatment to be produced in a timely manner, a multidisciplinary approach should be taken from the outset including stakeholders from academia, the pharmaceutical industry, and regulatory bodies keeping the patient as the key focus. Pre-clinical considerations for the development of a targeted host-directed therapy are discussed here.

Disciplines

Pharmacy and Pharmaceutical Sciences

Citation

O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J. Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery. Advanced Drug Delivery Reviews. 2016;102:33-54.

PubMed ID

27151307

DOI Link

10.1016/j.addr.2016.04.024

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Available for download on Saturday, July 01, 2017

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