Peer Reviewed

1

Document Type

Article

Publication Date

1-3-2009

Keywords

Velo-cardio-facial syndrome, 22q11.2 deletion syndrome, Spatial working memory, fMRI, Ageing, Schizophrenia.

Funder/Sponsor

The Healthcare Trust. South London and Maudsley NHS Trust.

Comments

The original article is available at www.biomedcentral.com

Abstract

22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders.

Disciplines

Medicine and Health Sciences | Psychiatry and Psychology

Citation

Azuma R, Daly EM, Campbell LE, Stevens AF, Deeley Q, Giampietro V, Brammer MJ, Glaser B, Ambery FZ, Morris RG, Williams SC, Owen MJ, Murphy DG, Murphy KC. Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study. Journal of Neurodevelopmental Disorders

PubMed ID

21547621

DOI Link

10.1007/s11689-009-9008-9

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Share

COinS