Peer Reviewed

1

Document Type

Article

Publication Date

1-2017

Keywords

25-OHD, 25-hydroxyvitamin D, Hypovitaminosis D, Psychosis, Schizophrenia, Vitamin D

Comments

This article is also available at https://www.journals.elsevier.com/psychiatry-research/

Abstract

People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of −11.14 ng/ml ±0.59 was found. 53 unique correlations between vitamin D and outcomes in people with psychosis were identified. The evidence base was broadly equivocal although season of blood sampling (67% of studies found a positive correlation with warmer seasons) and parathyroid hormone (100% of studies found a negative correlation) were associated with vitamin D levels. The most commonly non-correlated variables were: BMI (83% found no correlation), age (73%), gender (86%), smoking (100%), duration of illness (100%) and general assessment of functioning score (100%). In conclusion, whilst many unique correlates have been investigated, there is weak and inconclusive evidence regarding the consistency and meaning of the correlates of vitamin D levels in people with psychosis. Future longitudinal studies should consider the correlates of vitamin D in people with psychosis

Disciplines

Medicine and Health Sciences | Psychiatry and Psychology

Citation

Adamson J, Lally J, Gaughran F, Kirvoy A, Allen L, Stubbs B. Correlates of Vitamin D in Psychotic Disorders: A comprehensive Systematic Review. Psychiatry Research. 2017; 249:78-85.

PubMed ID

28081455

DOI Link

10.1016/j.psychres.2016.12.052

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Available for download on Monday, January 01, 2018

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