Peer Reviewed

1

Document Type

Article

Publication Date

5-2011

Keywords

Cystic Fibrosis, Hemolysis, Humans, Leukocyte Elastase, Peptides, Pseudomonas aeruginosa, Staphylococcus aureus

Funder/Sponsor

This publication has emanated from research conducted with the financial support of Science Foundation Ireland (05/RFP/CHE0063 and 06/RFP/CHO024/EC07 to M.D. and 06/RFP/CHO006 to C.M.H.)

Comments

The original article is available at http://aac.asm.org/content/55/5/2487.full.pdf+html

Abstract

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences

Citation

Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M. In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. Antimicrobial Agents and Chemotherapy 2011;55(5):2487-9

PubMed ID

21343449

DOI Link

10.1128/AAC.01384-10

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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