Peer Reviewed

1

Document Type

Article

Publication Date

30-10-2014

Keywords

Alkynes, Amino Acids, Azides, Blood Platelets, Epoxy Compounds, Humans, Peptides, Polyethylene Glycols, Polymers, Sulfhydryl Compounds

Funder/Sponsor

Irish Drug Delivery Network, Health Research Board

Comments

The original article is available at http://www.mdpi.com/

Abstract

Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies.

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences

Citation

O'Connor A, Marsat JN, Mitrugno A, Flahive T, Moran N, Brayden D, Devocelle M. Poly(Ethylene glycol)-based backbones with high peptide loading capacities. Molecules. 2014;19(11):17559-77

PubMed ID

25361422

DOI Link

10.3390/molecules191117559

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Share

COinS