Peer Reviewed

1

Document Type

Article

Publication Date

1-1-2014

Keywords

Bismuth, Bismuth Complexes, Organobismuth Compounds, Medicinal Chemistry, Gastrointestinal, H. pylori, Anti-Mcrobial, Anti-Leishmanial, Anti-Cancer

Comments

This article is also available at http://www.mdpi.com/1420-3049/19/9/15258

Abstract

Bismuth compounds have been used extensively as medicines and in particular for the treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective effects and efficacy in treating H. pylori infection it also has broad anti-microbial, anti-leishmanial and anti-cancer properties. Aspects of the biological chemistry of bismuth are discussed and biomolecular targets associated with bismuth treatment are highlighted. This review strives to provide the reader with an up to date account of bismuth-based drugs currently used to treat patients and discuss potential medicinal applications of bismuth drugs with reference to recent developments in the literature. Ultimately this review aims to encourage original contributions to this exciting and important field.

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences

Citation

Keogan DM, Griffith DM. Current and Potential Applications of Bismuth-Based Drugs. Molecules. 2014;19:15258-15297.

PubMed ID

25251194

DOI Link

10.3390/molecules190915258

Share

COinS