Peer Reviewed

1

Document Type

Article

Publication Date

28-11-2009

Keywords

Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, DNA, Drug Design, Histone Deacetylase 1, Histone Deacetylase Inhibitors, Humans, Inhibitory Concentration 50, Molecular Structure, Platinum Compounds

Comments

This article is also available from http://pubs.rsc.org

Abstract

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences

Citation

Griffith D, Morgan MP, Marmion CJ. A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity. Chem Commun (Camb). 2009;44:6735-6737

PubMed ID

19885462

DOI Link

10.1039/b916715c

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