Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, DNA, Drug Design, Histone Deacetylase 1, Histone Deacetylase Inhibitors, Humans, Inhibitory Concentration 50, Molecular Structure, Platinum Compounds
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.
Chemistry | Medicinal-Pharmaceutical Chemistry | Medicine and Health Sciences
Griffith D, Morgan MP, Marmion CJ. A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity. Chem Commun (Camb). 2009;44:6735-6737