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Submissions from 2014

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Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways., M Eugenia Delgado, Lydia Dyck, Maike A. Laussmann, and Markus Rehm

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Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome., Lorna Flanagan, Jasmin Schmid, Matthias Ebert, Pavel Soucek, Tereza Kunicka, Vaclav Liska, Jan Bruha, Paul Neary, Nicki Dezeeuw, Massimo Tommasino, Mazda Jenab, Jochen HM Prehn, and David J. Hughes

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Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort, David J. Hughes, Veronika Fedirko, Mazda Jenab, Lutz Schomburg, Catherine Meplan, Heinz Freisling, H B(as) Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tjonneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kuhn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H. Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose Sanchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E. Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramon Quiros, Magdalena Stepien, So Yeon Kong, Talita Duarte-Salles, Elio Riboli, and John E. Hesketh

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Solar photocatalysis for water disinfection: Materials and reactor design, Donal A. Keane, Kevin G. McGuigan, Pilar Fernandez Ibanez, M Inmaculada Polo-Lopez, Anthony J. Byrne, Patrick SM Dunlop, Kevin O'Shea, Dionysios D. Dionysiou, and Suresh C. Pillai

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The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes., Hans-Georg König, Karen S. Coughlan, Sinéad Kinsella, Bridget A. Breen, and Jochen HM Prehn

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Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis., Áine C. Murphy, Birgit Weyhenmeyer, Janis Noonan, Seán M. Kilbride, Sarah Schimansky, Kah P. Loh, D Kögel, A G. Letai, Jochen HM Prehn, and Brona M. Murphy

Submissions from 2013

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AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1., Ujval Anilkumar, Petronela Weisová, Heiko Düssmann, Caoimhín G. Concannon, Hans-Georg König, and Jochen HM Prehn

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Paracrine control of tissue regeneration and cell proliferation by Caspase-3., Karen Boland, Lorna Flanagan, and Jochen HM Prehn

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Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo., Gary P. Brennan, Eva M. Jimenez-Mateos, Ross C. McKiernan, Tobias Engel, Guri Tzivion, and David C. Henshall

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Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice., Mark Dunleavy, Giovanni Provenzano, David C. Henshall, and Yuri Bozzi

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Nitrogen and Copper doped solar light active TiO2 photocatalyst for water decontamination, Mike B. Fisher, Donal A. Keane, Pilar Fernandez-Ibanez, John Colreavy, Steven J. Hinder, Kevin G. McGuigan, and Suresh C. Pillai

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MicroRNAs in the pathophysiology and treatment of status epilepticus, David C. Henshall

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P2X receptors as targets for the treatment of status epilepticus., David C. Henshall, Miguel Diaz-Hernandez, M Teresa Miras-Portugal, and Tobias Engel

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Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young., Ma P. Kyithar, Caroline Bonner, Siobhan Bacon, Seán M. Kilbride, Jasmin Schmid, Rolf Graf, Jochen HM Prehn, and Maria M Byrne

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Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death., C Moran, Ava Sanz-Rodriguez, A Jimenez-Pacheco, J Martinez-Villareal, Ross C. McKiernan, Eva M. Jimenez-Mateos, C Mooney, Ina Woods, Jochen HM Prehn, David C. Henshall, and Tobias Engel

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Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach., Áine C. Murphy, Birgit Weyhenmeyer, Jasmin Schmid, Seán M. Kilbride, Markus Rehm, Heinrich J. Huber, C Senft, J Weissenberger, V Seifert, M Dunst, M Mittelbronn, D Kögel, Jochen HM Prehn, and Brona M. Murphy

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Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells., Egle Passante, Maximilian L. Würstle, Christian T. Hellwig, Martin Leverkus, and Markus Rehm

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Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability., Petronela Weisová, S P. Alvarez, Seán M. Kilbride, Ujval Anilkumar, B Baumann, Joaquin Jordán, Tytus Bernas, Henrich J. Huber, Heiko Düssmann, and Jochen HM Prehn

Submissions from 2012

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Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase., Isabela M. Aparicio-Erriu and Jochen HM Prehn

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Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward., Siobhan Bacon, Ma Peyh Kyithar, Jasmin Schmid, Syed R. Rizvi, Caroline Bonner, Rolf Graf, Jochen Prehn, and Maria M. Byrne

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Chronic Adolescent Exposure to Delta-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Indices of Dopaminergic, Endocannabinoid and GABAergic Pathways., Aine T. Behan, Magdalena Hryniewiecka, Colm MP O'Tuathaigh, Anthony Kinsella, Mary Cannon, Maria Karayiorgou, Joseph A. Gogos, John L. Waddington, and David R. Cotter

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Two step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate, David Davila, Niamh M. Connolly, Helena Bonner, Petronela Weisova, Heiko Dussmann, Caoimhin G. Concannon, Heinrich J. Huber, and Jochen HM Prehn

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Calpains are downstream effectors of bax-dependent excitotoxic apoptosis., Beatrice D'Orsi, Helena Bonner, Liam P. Tuffy, Heiko Düssmann, Ina Woods, Michael J. Courtney, Manus W. Ward, and Jochen HM Prehn

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TFAP2E-DKK4 and chemoresistance in colorectal cancer., Matthias PA Ebert, Marc Tänzer, Benjamin Balluff, Elke Burgermeister, Antje Karen Kretzschmar, David J Hughes, Reimo Tetzner, Catherine Lofton-Day, Robert Rosenberg, Anke C. Reinacher-Schick, Karsten Schulmann, Andrea Tannapfel, Ralf Hofheinz, Christoph Röcken, Gisela Keller, Rupert Langer, Katja Specht, Rainer Porschen, Jan Stöhlmacher-Williams, Tibor Schuster, Philipp Ströbel, and Roland M. Schmid

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Chronic hypobaric hypoxia increases isolated rat fast-twitch and slow-twitch limb muscle force and fatigue., R El-Khoury, Aidan Bradford, and Ken D. O'Halloran

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P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control., Tobias Engel, Alba Jimenez-Pacheco, Maria Teresa Miras-Portugal, Miguel Diaz-Hernandez, and David C. Henshall

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Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus., Maura Heverin, Gary P. Brennan, Christian J. Koehler, Achim Treumann, and David C. Henshall

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A structured approach to the study of metabolic control principles in intact and impaired mitochondria., Heinrich J. Huber, Niamh MC Connolly, Heiko Dussmann, and Jochen HM Prehn

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Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation., Crina-Maria Ionescu, Radka Svobodová Vařeková, Jochen HM Prehn, Heinrich J. Huber, and Jaroslav Koča

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Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons., Hans-Georg König, Beau J. Fenner, Jennifer C. Byrne, Robert F. Schwamborn, Tytus Bernas, Caroline A. Jefferies, and Jochen HM Prehn

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Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis., Ross C. McKiernan, Eva M. Jimenez-Mateos, Isabella Bray, Tobias Engel, Gary P. Brennan, Takanori Sano, Zuzanna Michalak, Catherine Moran, Norman Delanty, Michael Farrell, Donncha O'Brien, Robert Meller, Roger P. Simon, Raymond L. Stallings, and David C. Henshall

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Differential DNA methylation patterns define status epilepticus and epileptic tolerance., Suzanne F C Miller-Delaney, Sudipto Das, Takanori Sano, Eva M. Jimenez-Mateos, Kenneth Bryan, Patrick G. Buckley, Raymond L. Stallings, and David C. Henshall

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MicroRNA-34a upregulation during seizure-induced neuronal death., Takanori Sano, J P. Reynolds, Eva M. Jimenez-Mateos, S Matsushima, W Taki, and David C. Henshall

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SiteBinder: an improved approach for comparing multiple protein structural motifs., David Sehnal, Radka Svobodová Vařeková, Heinrich J. Huber, Stanislav Geidl, Crina-Maria Ionescu, Michaela Wimmerová, and Jaroslav Koča

Submissions from 2011

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Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release., Heinrich J. Huber, Heiko Düssmann, Seán M. Kilbride, Markus Rehm, and Jochen HM Prehn

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Elimination of water pathogens with solar radiation using and automated sequential batch CPC Reactor, M I. Polo-Lopez, P Fernandez-Ibanez, E Ubomba-Jaswa, C Navntoft, I Garcia-Fernandez, P SM Dunlop, J A. Byrne, M Schmidt, and Kevin G. McGuigan

Submissions from 2010

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INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighbouring Cells, Caroline Bonner, Siobhan Bacon, Caoimhín G. Concannon, Seyed R. Rizvi, Mathurin Baquie, Angela M. Farrelly, Seán M. Kilbride, Heiko Düssmann, Manus W. Ward, Chantal M. Boulanger, Claes B. Wollheim, Rolf Graf, Maria M. Byrne, and Jochen HM Prehn

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AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis., Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward, and Jochen HM Prehn

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Expanding the substantial interactome of NEMO using protein microarrays., Beau J. Fenner, Michael Scannell, and Jochen H M Prehn

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XIAP impairs Smac release from the mitochondria during apoptosis., Lorna Flanagan, Jordi Sebastia, Liam P. Tuffy, Aidan Spring, A Lichawska, Marc Devocelle, Jochen HM Prehn, and Markus Rehm

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Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation., Christian T. Hellwig, Agnieszka H. Ludwig-Galezowska, Caoimhín G. Concannon, David W. Litchfield, Jochen H M Prehn, and Markus Rehm

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Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death., Heinrich J. Huber, Maike A. Laussmann, Jochen HM Prehn, and Markus Rehm

Submissions from 2009

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Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays., Beau J. Fenner, Michael Scannell, and Jochen H M Prehn

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Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review., Suzanne Hector and Jochen H M Prehn

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Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents., David C. Henshall, Nick Dürmüller, H Steve White, Robert Williams, Paul Moser, Mark Dunleavy, and Peter H. Silverstone

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Dynamics of outer mitochondrial membrane permeabilization during apoptosis., Markus Rehm, Heinrich J. Huber, Christian T. Hellwig, Sergio Anguissola, Heiko Düssmann, and Jochen HM Prehn

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Angiogenin protects motoneurons against hypoxic injury., J Sebastià, D Kieran, B Breen, M A. King, D F. Netteland, D Joyce, S F. Fitzpatrick, C T. Taylor, and Jochen HM Prehn

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Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development., Jacqueline Whyte, Orla Bergin, Alessandro Bianchi, Sara McNally, and Finian Martin

Submissions from 2008

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Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice., Genshin Mouri, Eva Jimenez-Mateos, Tobias Engel, Mark Dunleavy, Seiji Hatazaki, Alexia Paucard, Satoshi Matsushima, Waro Taki, and David C. Henshall

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Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures., Niamh Murphy, Akitaka Yamamoto, and David C. Henshall

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Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling., Gerard J. O'Sullivan, Mark Dunleavy, Kerstin Hakansson, Mario Clementi, Anthony Kinsella, David T. Croke, John Drago, Allen A. Fienberg, Paul Greengard, David R. Sibley, Gilberto Fisone, David C. Henshall, and John L. Waddington

Submissions from 2007

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Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons., Hans-Georg König, Markus Rehm, Daniel Gudorf, Stan Krajewski, Atan Gross, Manus W. Ward, and Jochen HM Prehn