Date of Award
PhD (Doctor of Philosophy)
Professor Mauro Adamo.
The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity. In Chapter 2 we described a Catalytic Asymmetric Conjugate Addition of isocyanoacetates to 4-nitro-5-styrylisoxmles. In Chapter 3 we described a new strategy for the preparation of medium sized oxepanes oxocanes and oxonanes. In Chapter 4 we described a novel route to alkene-hctionalised monobactams and their potential in diversity oriented synthesis is still in progress.
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Disetti, P. Progresses on the development of stereoselective [2+2], [2+3] and [4+3] cycloadditions. [PhD Thesis]. Dublin : Royal College of Surgeons in Ireland, 2011.