Date of Award

2011

Document type

Thesis

Degree Name

PhD (Doctor of Philosophy)

First Supervisor

Professor Mauro Adamo.

Keywords

Chemistry, Pharmaceutical.

Abstract

The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity. In Chapter 2 we described a Catalytic Asymmetric Conjugate Addition of isocyanoacetates to 4-nitro-5-styrylisoxmles. In Chapter 3 we described a new strategy for the preparation of medium sized oxepanes oxocanes and oxonanes. In Chapter 4 we described a novel route to alkene-hctionalised monobactams and their potential in diversity oriented synthesis is still in progress.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

File Size

10,186

Comments

A thesis submitted to the Royal College of Surgeons in Ireland for the degree of Doctor of Philosophy from the National University of Ireland in 2011.

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