Date of Award
2011
Document type
Thesis
Degree Name
PhD (Doctor of Philosophy)
First Supervisor
Professor Mauro Adamo.
Keywords
Chemistry, Pharmaceutical.
Abstract
The present work dealt with the preparation of some key intermediates and their use for the generation of chemical diversity. In Chapter 2 we described a Catalytic Asymmetric Conjugate Addition of isocyanoacetates to 4-nitro-5-styrylisoxmles. In Chapter 3 we described a new strategy for the preparation of medium sized oxepanes oxocanes and oxonanes. In Chapter 4 we described a novel route to alkene-hctionalised monobactams and their potential in diversity oriented synthesis is still in progress.
Link to this item at
http://epubs.rcsi.ie/phdtheses/40
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.
File Size
10,186
Citation
Disetti, P. Progresses on the development of stereoselective [2+2], [2+3] and [4+3] cycloadditions. [PhD Thesis]. Dublin : Royal College of Surgeons in Ireland, 2011.
Comments
A thesis submitted to the Royal College of Surgeons in Ireland for the degree of Doctor of Philosophy from the National University of Ireland in 2011.