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Theses/Dissertations from 2014

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Investigating novel mechanisms of metastasis in endocrine resistant breast cancer., Jarlath Bolger

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The functional roles of GPVI, GPIba, and PARs in the generation of platelet-derived reactive oxygen species., Naadiya Carrim

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Effectiveness of medicines review with web-based pharmaceutical treatment algorithms in reducing potentially inappropriate prescribing in older people in primary care: a cluster randomised trial (OPTI-SCRIPT study), Barbara Clyne

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In vitro and in vivo elucidation of AMPK as a new therapeutic target in Amyotrophic Lateral Sclerosis, Karen Coughlan

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The role of osteoprotegerin and receptor activator of nuclear factor kappa-betta ligand in vascular calcification and the influence of insulin and liraglutide on this process in type 2 diabetes mellitus., Colin Davenport

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Development of Phase Transfer Catalysed Cyclopropanation and Related Processes, Claudia Del Fiandra

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Myelin Abnormalities in Schizophrenia: Insights from Proteomic Investigations of Post-Mortem Schizophrenia and Pre-Clinical Animal Models, Lorna Farrelly

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Exploring the effects of Cadherin-derived Peptides on Platelet and Endothelial Cell Function, Kalyan Golla

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Physiological Impact of Lipoxin A4 on Cystic Fibrosis Bronchial Epithelium, Gerard Higgins

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Quality of life of Bahraini women with breast cancer, Ghufran Ahmed Jassim

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Peptide Prodrugs: Using Host Defence Peptides as Therapeutic Anticancer Agents, Graeme Joseph James Kelly

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The Actions of Ursodeoxycholic Acid and its derivatives on Colonic Epithelial Transport and Barrier Function, Orlaith B. Kelly

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Investigation into the potential of Human Amniotic Fluid-Derived Stem Cells for use in Orthopaedic Tissue Engineering, Cai Lloyd-Griffith

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Individual Platelet Adhesion (iPA): A novel assay of platelet function, Ana Lopez Alonso

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The Impact of a Changed Approach to Analgesia and Sedation Management in the Paediatric Intensive Care Unit, Claire Magner

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Investigation into the role of La/SS-B in Interferon regulation and its relevance in health and human disease, Rebecca G. Mahony

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Heritable and environmental determinants of platelet response to acetylsalicylic acid/, Andrew Maree

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Changes in the Ultrastructural Features of Estrogen Deficient Ovine Bone, Peter Mauer

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Effectiveness of conventional versus virtual reality based vestibular rehabilitation in the treatment of dizziness, gait and balance impairment in adults with unilateral peripheral vestibular hypofunction, Dara Meldrum

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Time to hospital presentation in acute ischaemic stroke, Lisa Mellon

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Molecular exploration of tumour cell-induced platelet activation and its relevance in the treatment of cancer., Annachiara Mitrugno

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An evaluation of impairment, mobility and quality of life in Polio survivors, change in muscle strength over time and the effects of an arm ergometry aerobic exercise programme., Deirdre E. Murray

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Phenotypic characterisation of a novel mutant mouse with target deletion of dysbindin-1A in relation to the schizophrenia risk gent DTNBP1., Emilie Petit

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Controlled Release of Bioactive Molecules from Collagen-Based Scaffolds for Bone Repair, Elaine Quinlan

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Organocatalysis via covalent and non covalent bonding: synthetic applications and mechanistic insights., Diana Salazar Illera

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Studies Concerning the Use of Activated Alkenes in Enantioselective Reactions., Michela Scagnetti

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Effects of schizophrenia, bipolar disorder, and haloperidol on the hippocampus: a proteomic approach., Klaus O. Schubert

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Intrauterine Fetal Growth Restriction - New Insights into Prenatal Detection, Definition, Surveillance and Delivery, Julia Unterscheider

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Analysis of the Effects of HSF1 Inhibition in Colon Cancer, Linda Marie Williams

Theses/Dissertations from 2013

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The Application of Quantitative Magnetic Resonance Imaging (QMRI) to Identify Neuroanatomical Endophenotypes in Epilepsy, Saud Alhusaini

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A School-based Trial Protocol in Community Promotion of Solar Water Disinfection (SODIS): A Case Study of Ndagwe Sub County, Central Uganda, Jacent Kamuntu Asiimwe

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A novel role of lipid rafts in regulating CD44-dependent breast cancer cell migration., Irina S. Babina

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The epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and an investigation of a novel therapeutic peptide conjugate., Liam Burke

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AMP-Activated Protein Kinase (AMPK) Activation and Signalling Following Neuronal Excitotoxicity, Niamh M C Connolly

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Elucidating the role of microRNA-497 and WEE1 in neuroblastoma disease pathogenesis., Laura M. Creevey

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Public policy and health behaviour: An investigation of tobacco control policy and smoking in Ireland, Laurie Michelle Currie

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The role of platelets in the pathology of cancer., Karl Egan

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An Investigation of Cannabis Use and Childhood Trauma in Relation to Psychotic Symptoms and Their Outcomes: a Population-Based Follow-up Study of Irish Adolescents, Michelle Harley

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Functional analysis of miRNA in chemotherapy resistant neuroblastoma., Harry Harvey

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The Role of Micrornas in Alpha-1 Antitrypsin Deficiency Disease., Tidi M. Hassan

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Modulation of Chloride Secretion by Bile Acids in Airway Epithelial Cells., Siobhan M. Hendrick

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The development of novel siRNA nanoparticles for delivery to pulmonary epithelial cells, Alan J. Hibbitts

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The role of oestrogen induced signalling in the suppression of malignant mesothelioma cell growth., Cormac Jennings

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Molecular signalling pathways involved in AMPK-mediated neuronal preconditioning and optimisation of a high content screening assay to monitor excitotoxic neuronal death., Ujval A. Kumar

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Elucidating the role of metastasis suppressor microRNA-335 in neuroblastoma disease pathogenesis., Jennifer Lynch

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The "humanisation" of medicine? : the feminisation of medicine: a qualitative study of the career experiences of female doctors and implications for human resources management in Ireland., Sara McAleese

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Genome-wide mapping of markers for epilepsy predisposition and treatment., Mark McCormack

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A role for microRNA-29a mediating ER stress-induced apoptosis in neuronal cells in the mouse central nervous system., Katie Nolan

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Novel multi-functional metallo-drug candidates with enhanced selectivity and activity towards cancer cells., James Parker

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Estrogen regulation of the Potassium Channel KCNQ1:KCNE3 in Colonic Epithelium, Raphael Rapetti-Mauss

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Pathways to human platelet activation : convergence of streptococcus pneumoniae and streptococcus oralis at a universal actor, Fc gamma RIIA, Dorothea O. Tilley

Theses/Dissertations from 2012

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Stereoselective Preparation of Enantiopure Abasic Nucleosides and 4-Nitroisoxazoles, Gea Bellini

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Prescribing in Ireland : assessing indicators of prescribing quality and efficiency in older populations., Caitriona Cahir

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Molecular mechanisms underlying staphylococcal induced osteomyelitis., Tania Claro

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Investigating the Role of Life Events on Youth Mental Health Outcomes: A Population-Based Follow-Up Study., Dearbhla Connor

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Identification of novel biomarkers in postmenopausal osteoporosis, Laura Corrigan

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Symptoms, Symptom Clusters and Cytokine Activity in Women with Breast Cancer, Suzanne Denieffe

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Characterisation of calpain activation in response to excitotoxic events in primary neurons, Beatrice D'Orsi

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The role of LIN28B and XRN2 on microRNA regulation in neuroblastoma., Raquel D. Fernandez

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Bone microstructure, turnover and peri-articular osteopathies., Jane C. Holland

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Development of the biomarker S100β in metastatic endocrine resistant breast cancer, Éamon Hughes

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Molecular Imaging of Glioblastoma (GBM) in In Vivo Models: Validation of Imageable Mouse Models of GBM and Novel Anti-GBM Therapeutic Approaches, Monika Agnieszka Jarzabek

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An Epidemiological Investigation of Adolescents and Symptomatic High Risk for Psychosis, Ian Kelleher

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A protease resistant insulin like growth factor binding protein 4 as a treatment for prostate cancer, Gemma Kirwan

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An Investigation into the Genetic Basis of Familial Interstitial Nephritis, Peter Lavin

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Regulations of IRF5 activity in the TLR7 and type I IFN pathways, Elisa Lazzari

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The development of novel collagen-glycosaminoglycan scaffold for in vitro mesenchymal stem cell chondrogenesis, Amos Matsiko

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The vascularisation of collagen-glycosaminoglycan scaffolds for bone tissue engineering., Tara M. McFadden

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Chasing electrons : exploring the redox balance of platelet functions, Desmond D. Murphy

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An investigation of event-related potentials in adolescents with psychotic-like experiences, Jennifer Murphy

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A Novel in vitro Microfluidic Flow Assay for Quantitative Assessment of Initial Platelet Adhesion on von Willebrand Factor in Arterial Flowing Blood: Assessment of this Platelet Function Assay in Healthy and Cardiovascular Disease States, Sinéad O'Brien

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Evaluation of gene-environmental interactions and regional loss of receptors in preclinical genetic models of schizophrenia., Claire O'Leary

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Reality or rhetoric? Community involvement in primary care in north inner city Dublin., Fiona O'Reilly

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Non-Cardiac Chest Pain: the Role of Physical, Psychosocial, and Service-Related Factors in the Persistence of Pain and Health Service Use, Aisling Sheehan

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The role of IGF-I signalling in the pathogenesis of breast cancer : therapeutic potential of a protease resistant IGF binding protein 4 (IGFBP4), Yvonne E. Smith

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The application of voxel-based methods to magnetic resonance imaging in the study of psychiatric disorder., Frederick Sundram

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Aromatase inhibitor specific metastasis is driven by the steroid receptor coactivator SRC-1, Sarah M. Theissen

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The steroid receptor coactivator, SRC-1, can function as a transcriptional corepressor to selectively suppress anti-tumourigenic target genes in Tamoxifen resistant breast cancer, Claire A. Walsh

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Staphylococcus induced bone loss and destruction in osteomyelitis, Amro Widaa

Theses/Dissertations from 2011

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Cellular and molecular basis of mammary microcalcifications, Rachel Cox

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Progresses on the development of stereoselective [2+2], [2+3] and [4+3] cycloadditions., Paolo Disetti

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Health Impact Assessment of Solar Disinfection (SODIS) of Drinking Water in Three African Countries, Martella du Preez

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A multi-centre randomised controlled trial evaluating exercise and manual therapy for osteoarthritis of the hip., Helen P. French

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An exercise programme for patients with intermittent claudication: randomised trial of health outcomes and cost analysis, Marie Guidon

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Investigation of signalling pathways in high grade glioma in order to predict responsiveness to tyrosine kinase inhibitors., Rachel K. Howley

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Development of Nano- and Microparticle Technologies for Targeted Gene Silencing through RNA Interference Manipulation of the Immune Response in Inflammatory Lung Disease, Ciara Kelly

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Modulation of apoptosis signalling by proteasome inhibition : a single cell analysis, Maike A. Laussmann

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The use of collagen-based bone graft substitutes for orthopaedic regenerative medicine., Frank G. Lyons

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Gait impairment in cervical spondylotic myelopathy: Analysis, impact on function, and effect of surgical intervention, Ailish Marie Malone

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Identifying new transcriptional targets for SRC-1 in breast cancer, Damian McCartan

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Cardiovascular Genetics: Candidate Gene, Candidate Pathway and Whole Genome Analyses, Nina McCarthy

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Genome-wide mapping of MYCN transcription factor binding sites and identification of clinically relevant targets in neuroblastoma., Derek Murphy

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Estrogen receptor-coactivator interactions in resistance to aromatase inhibitor treatment for breast cancer., Jane O'Hara

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Histological evaluation of putative biomarkers in prostate cancer, Gillian O'Hurley

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Real-time imaging analysis and functional characterisation of transcription factor NF-kappaB activation in a model of excitotoxic injury in rat neurons., Robert F. Schwamborn

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Characterisation of angiogenin uptake and signalling in astrocytes, Alexandra Skorupa

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The role of tyrosine phosphorylation in the regulation of Ro52, Kevin B. Stacey

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Research in pharmacy education - lessons from programme design and development at a new School of Pharmacy, Judith Strawbridge

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The role of T-cell immunoglobulin and mucin-domain-containing molecules in inflammation in the cystic fibrosis airways, Isabel Vega-Carrasca

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The Role of HIF Hydroxylases in the Regulation of Colonic Epithelial Ion Transport, Joseph Bernard Jude Ward