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Theses/Dissertations from 2013

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The Application of Quantitative Magnetic Resonance Imaging (QMRI) to Identify Neuroanatomical Endophenotypes in Epilepsy, Saud Alhusaini

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A novel role of lipid rafts in regulating CD44-dependent breast cancer cell migration., Irina S. Babina

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The epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and an investigation of a novel therapeutic peptide conjugate., Liam Burke

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AMP-Activated Protein Kinase (AMPK) Activation and Signalling Following Neuronal Excitotoxicity, Niamh M C Connolly

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Investigation of the role of Aspergillus fumigatus colonisation in the cystic fibrosis airway epithelium, Catherine Anne Coughlan

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Elucidating the role of microRNA-497 and WEE1 in neuroblastoma disease pathogenesis., Laura M. Creevey

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The role of platelets in the pathology of cancer., Karl Egan

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An Investigation of Cannabis Use and Childhood Trauma in Relation to Psychotic Symptoms and Their Outcomes: a Population-Based Follow-up Study of Irish Adolescents, Michelle Harley

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Functional analysis of miRNA in chemotherapy resistant neuroblastoma., Harry Harvey

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The role of oestrogen induced signalling in the suppression of malignant mesothelioma cell growth., Cormac Jennings

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Molecular signalling pathways involved in AMPK-mediated neuronal preconditioning and optimisation of a high content screening assay to monitor excitotoxic neuronal death., Ujval A. Kumar

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Elucidating the role of metastasis suppressor microRNA-335 in neuroblastoma disease pathogenesis., Jennifer Lynch

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Genome-wide mapping of markers for epilepsy predisposition and treatment., Mark McCormack

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A role for microRNA-29a mediating ER stress-induced apoptosis in neuronal cells in the mouse central nervous system., Katie Nolan

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Novel multi-functional metallo-drug candidates with enhanced selectivity and activity towards cancer cells., James Parker

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Pathways to human platelet activation : convergence of streptococcus pneumoniae and streptococcus oralis at a universal actor, Fc gamma RIIA, Dorothea O. Tilley

Theses/Dissertations from 2012

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Stereoselective Preparation of Enantiopure Abasic Nucleosides and 4-Nitroisoxazoles, Gea Bellini

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Prescribing in Ireland : assessing indicators of prescribing quality and efficiency in older populations., Caitriona Cahir

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Molecular mechanisms underlying staphylococcal induced osteomyelitis., Tania Claro

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Investigating the Role of Life Events on Youth Mental Health Outcomes: A Population-Based Follow-Up Study., Dearbhla Connor

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Identification of novel biomarkers in postmenopausal osteoporosis, Laura Corrigan

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Symptoms, Symptom Clusters and Cytokine Activity in Women with Breast Cancer, Suzanne Denieffe

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Characterisation of calpain activation in response to excitotoxic events in primary neurons, Beatrice D'Orsi

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Bone microstructure, turnover and peri-articular osteopathies., Jane C. Holland

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Development of the biomarker S100β in metastatic endocrine resistant breast cancer, Éamon Hughes

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Molecular Imaging of Glioblastoma (GBM) in In Vivo Models: Validation of Imageable Mouse Models of GBM and Novel Anti-GBM Therapeutic Approaches, Monika Agnieszka Jarzabek

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An Epidemiological Investigation of Adolescents and Symptomatic High Risk for Psychosis, Ian Kelleher

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A protease resistant insulin like growth factor binding protein 4 as a treatment for prostate cancer, Gemma Kirwan

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An Investigation into the Genetic Basis of Familial Interstitial Nephritis, Peter Lavin

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Regulations of IRF5 activity in the TLR7 and type I IFN pathways, Elisa Lazzari

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The development of novel collagen-glycosaminoglycan scaffold for in vitro mesenchymal stem cell chondrogenesis, Amos Matsiko

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The vascularisation of collagen-glycosaminoglycan scaffolds for bone tissue engineering., Tara M. McFadden

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Blood-brain barrier impairment and immunity in epilepsy : role of immunoglobulins G and biomarker identification., Zuzanna Michalak

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Chasing electrons : exploring the redox balance of platelet functions, Desmond D. Murphy

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An investigation of event-related potentials in adolescents with psychotic-like experiences, Jennifer Murphy

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A Novel in vitro Microfluidic Flow Assay for Quantitative Assessment of Initial Platelet Adhesion on von Willebrand Factor in Arterial Flowing Blood: Assessment of this Platelet Function Assay in Healthy and Cardiovascular Disease States, Sinéad O'Brien

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Evaluation of gene-environmental interactions and regional loss of receptors in preclinical genetic models of schizophrenia., Claire O'Leary

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Reality or rhetoric? Community involvement in primary care in north inner city Dublin., Fiona O'Reilly

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Non-Cardiac Chest Pain: the Role of Physical, Psychosocial, and Service-Related Factors in the Persistence of Pain and Health Service Use, Aisling Sheehan

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The role of IGF-I signalling in the pathogenesis of breast cancer : therapeutic potential of a protease resistant IGF binding protein 4 (IGFBP4), Yvonne E. Smith

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The application of voxel-based methods to magnetic resonance imaging in the study of psychiatric disorder., Frederick Sundram

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Aromatase inhibitor specific metastasis is driven by the steroid receptor coactivator SRC-1, Sarah M. Theissen

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The steroid receptor coactivator, SRC-1, can function as a transcriptional corepressor to selectively suppress anti-tumourigenic target genes in Tamoxifen resistant breast cancer, Claire A. Walsh

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Staphylococcus induced bone loss and destruction in osteomyelitis, Amro Widaa

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Characterisation of the SPRY Domain Containing TRIM, TRIM68, as a Regulator of Antiviral Innate Immune Responses, Claire M. Wynne

Theses/Dissertations from 2011

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Cellular and molecular basis of mammary microcalcifications, Rachel Cox

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Progresses on the development of stereoselective [2+2], [2+3] and [4+3] cycloadditions., Paolo Disetti

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Health Impact Assessment of Solar Disinfection (SODIS) of Drinking Water in Three African Countries, Martella du Preez

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A multi-centre randomised controlled trial evaluating exercise and manual therapy for osteoarthritis of the hip., Helen P. French

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An exercise programme for patients with intermittent claudication: randomised trial of health outcomes and cost analysis, Marie Guidon

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Investigation of signalling pathways in high grade glioma in order to predict responsiveness to tyrosine kinase inhibitors., Rachel K. Howley

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Development of Nano- and Microparticle Technologies for Targeted Gene Silencing through RNA Interference Manipulation of the Immune Response in Inflammatory Lung Disease, Ciara Kelly

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Modulation of apoptosis signalling by proteasome inhibition : a single cell analysis, Maike A. Laussmann

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Therapeutic Aerosol Bioengineering to treat Mycobacterium tuberculosis infection, Ciaran Lawlor

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The use of collagen-based bone graft substitutes for orthopaedic regenerative medicine., Frank G. Lyons

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Gait impairment in cervical spondylotic myelopathy: Analysis, impact on function, and effect of surgical intervention, Ailish Marie Malone

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Identifying new transcriptional targets for SRC-1 in breast cancer, Damian McCartan

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Cardiovascular Genetics: Candidate Gene, Candidate Pathway and Whole Genome Analyses, Nina McCarthy

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Genome-wide mapping of MYCN transcription factor binding sites and identification of clinically relevant targets in neuroblastoma., Derek Murphy

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An Investigation of Differentially Expressed miRNA in the Cystic Fibrosis Airway Epithyelium, Irene K. Oglesby

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Estrogen receptor-coactivator interactions in resistance to aromatase inhibitor treatment for breast cancer., Jane O'Hara

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Histological evaluation of putative biomarkers in prostate cancer, Gillian O'Hurley

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Real-time imaging analysis and functional characterisation of transcription factor NF-kappaB activation in a model of excitotoxic injury in rat neurons., Robert F. Schwamborn

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Characterisation of angiogenin uptake and signalling in astrocytes, Alexandra Skorupa

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The role of tyrosine phosphorylation in the regulation of Ro52, Kevin B. Stacey

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Research in pharmacy education - lessons from programme design and development at a new School of Pharmacy, Judith Strawbridge

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The role of T-cell immunoglobulin and mucin-domain-containing molecules in inflammation in the cystic fibrosis airways., Isabel Vega-Carrascal

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The Role of HIF Hydroxylases in the Regulation of Colonic Epithelial Ion Transport, Joseph Bernard Jude Ward

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Use of Aliphatic and Aromatic Styryl Isoxazoles as Versatile Intermediates for the Synthesis of Peptidomimetics, Drug Molecules and Optically Active Building Blocks for Organic Synthesis, Robert Wells

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Correlation Analysis of Treatment Sensitivity and Protein Expresson of pro- and anti-apoptotic Proteins & the Role of the BH3-only Protein Bim during Apoptosis of malignant Gliomas, Birgit Claudia Weyhenmeyer

Theses/Dissertations from 2010

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The role of lipoxin A4 in regulating ion transport and airway surface liquid dynamics in cystic fibrosis bronchial epithelium, Mazen Al-Alawi

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Effect of gene knockout and NMDA receptor modulation on cell survival and neuronal stem cell fate in in vitro and in vivo models of excitotoxicity., Eva C. Bunk

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Bidirectional receptor crosstalk in breast cancer: the role of c-myc and coregulatory proteins and future implications for cancer treatment., Dearbhaile C. Collins

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Modified host defence peptides as beta-lactamase-dependent antibiotic prodrug candidates., Stephane Desgranges

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The effect of the X-linked Inhibitor-of-Apoptosis Protein on the release of Smac from the mitochondria during Apoptosis, Lorna Flanagan

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RuvB12 as a regulator of hTERT, Padraic Flavin

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Functional studies of microRNAs involved with ATRA induced differentiation of neuroblastoma cells, Niamh Foley

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Real-Time Single Cell Analyses of Apoptosis Initiation and Execution Signalling in Human Cancer Cells, Christian Timotheus Hellwig

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The molecular mechanisms of streptococcus gordonii-platelet interactions involved in the pathogenesis of cardiovascular infection, Ciara Keane

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Analysis of osteogenesis on a novel collagen glycosaminoglycan scaffold- in vitro application for bone tissue engineering, Michael Keogh

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Design and evaluation of novel anti-tubulin agents selectively targeting parasitic tubulin, Christine Mara

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Molecular epidemiology of carriage and disease associated strains of serogroup C Neisseria meningitidis, in the Irish Republic following the introduction of the meningococcal conjugate vaccine., Robert Martin Mulhall

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The effect of mean pore size in collagen-glycosaminoglycan scaffolds on cell migration and differentiation for bone tissue engineering applications, Ciara M. Murphy

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Examination of formulation and process factors on the characteristics of fast dissolving and fast disintegrating tablets manufactured by a direct compression process., Ritesh M. Pabari

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Towards the Asymmetric Synthesis of 1,2-Oxazines, Linda Piras

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Detection and characterisation of heat shock responses in relation to cell death signaling in human cancer cells, Lavanya Ramapathiran

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Optimisation, validation and application of quantitative magnetic resonance image analysis techniques to study the endophenotypic potential of brain morphology in temporal lobe epilepsy, Catherine Scanlon

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Bioengineered microparticles for controlled drug delivery to the lungs, Neeraj Sivadas

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In-vitro osteogenesis is affected by composition and stiffness of collagen-GAG scaffold., Claire M. Tierney

Theses/Dissertations from 2009

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New carboxylate and hydroxamate inhibitors of prostaglandin-H-synthase and their metal complexes, Ahmed Al Agha

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Development of novel collagen-calcium phosphate scaffolds suitable for bone tissue-engineering and bone repair, Amir A. Al-Munajjed

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Gene expression profiling of molecular target genes which are regulated by hepatocyte nuclear factor 1 Alpha (HNF1A) in rat insulin-secreting cells: role in HNF1A-MODY, Caroline Bonner

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The role of cytosolic phospholipase A2 in the rapid oestrogen-induced signalling responses in breast cancer cells, Francesco Caiazza

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Extrinsic and intrinsic regulation of breast cancer progression - promoting an aggressive phenotype via alterations in cellular populations and subcellular compartments, Simona Donatello

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Potential hazards in the medication use process at the hospital community interface and a strategy to reduce them., Tamasine Grimes

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Skin and bone : the effect of age and estrogen deficiency., Claragh Healy

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An investigation of the neurocognitive phenotype of 22Q11.2 deletion syndrome across developmental stages., Sarah A. Howley

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Design, synthesis and antibiotic susceptibility evaluation of prodrugs of peptides and anti-inflammatory agens for colonic delivery, David Andrew Kennedy

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Anatomists and geometers : a selection from the published work., T Clive Lee

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The effect of repositioning 3 hourly at night, using the 30 degree tilt, on the incidence of pressure ulcers, in older persons at risk of pressure ulcer development hospitalised in long-term care settings, Zena EH Moore