Document Type

Article

Publication Date

2-2011

Keywords

Mineralocorticoid Receptor, Electrolyte Transport, Hypertension, Polycystic Kidney Disease

Comments

This article is available at http://arjournals.annualreviews.org.

Abstract

The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney, and contributes to both homeostatic whole body electrolyte balance and also to the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron, and how these responses are integrated into the regulation of renal physiology by aldosterone.

Disciplines

Medical Molecular Biology | Medical Sciences

Citation

Thomas W, Harvey BJ. Mechanisms underlying rapid aldosterone effects in the kidney. Annual Review of Physiology. 2011;73:335-57.

PubMed ID

20809792

DOI Link

10.1146/annurev-physiol-012110-142222