Peer Reviewed

1

Document Type

Article

Publication Date

8-2010

Keywords

Aldosterone, Kidney, Protein Kinase D, EGFR, Polycystic Kidney Disease, Mitogen Activated Protein Kinase

Comments

The original publication is available at http://www.sciencedirect.com

Abstract

Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.

Disciplines

Medical Molecular Biology | Medical Sciences

Citation

Thomas W. Dooley R. Harvey BJ. Aldosterone as a renal growth factor. Steroids. 2010; 75(8-9)550-554.

PubMed ID

19782095

DOI Link

10.1016/j.steroids.2009.09.008

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