Document Type

Article

Publication Date

7-2011

Keywords

Aldosterone, Non-genomic, Mineralocorticoid Receptor, ENaC, Kidney, Protein Kinase D

Comments

This article is also available at http://www.sciencedirect.com/science/article/pii/S0303720711003996

Abstract

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.

Disciplines

Medical Molecular Biology | Medical Sciences

Citation

Dooley R, Harvey BJ, Thomas W. Non-genomic actions of aldosterone: From receptors and signals to membrane targets. Molecular and Cellular endocrinology. 2011 [Epub ahead of print]

PubMed ID

21801805

DOI Link

10.1016/j.mce.2011.07.019


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