Peer Reviewed

1

Document Type

Article

Publication Date

1-2013

Keywords

Anti-Asthmatic Agents, Asthma, Bronchi, Cell Proliferation, Disease Management, Genetic Predisposition to Disease, Humans, MicroRNAs, Polymorphism, Single Nucleotide

Comments

This is a non-final version of an article published in final form in Current Opinion in Pulmonary Medicine 2013 Jan;19(1):66-72. doi: 10.1097/MCP.0b013e32835a5bc8. http://journals.lww.com/

Abstract

PURPOSE OF REVIEW: Asthma is a global disease affecting millions of people. Current treatments are largely symptomatic and, although often effective, can be associated with various side effects. microRNAs (miRNAs/miRs) are regulatory RNAs that affect protein synthesis. They represent new therapeutic targets, and medicines that target specific miRNAs may have potential in the treatment of asthma.

RECENT FINDINGS: There have been a number of studies in the field of miRNA that implicate specific miRNAs in the pathophysiology of asthma. For example, studies using mouse models have identified miRNAs that are altered in response to allergen challenge. Certain miRNAs that are involved in the regulation of interleukin-13 and the TH2 response, key components of the asthmatic response, have been shown to be amenable to modulation by premiRs and antimiRs. Other studies have identified miRNAs that are implicated in bronchial smooth muscle hyperresponsiveness and proliferation. Single-nucleotide polymorphisms in miRNA responsive elements within asthma susceptibility genes, and also in miRNAs themselves, can also contribute to the asthma phenotype.

SUMMARY: Developing miRNA-based medicines to treat the pulmonary manifestations of asthma could yield therapeutics with new properties that have the potential to treat both the inflammation and hyperresponsivesness associated with this disease.

Disciplines

Medicine and Health Sciences

Citation

Greene CM, Gaughan KP. microRNAs in asthma: potential therapeutic targets. Current Opinion in Pulmonary Medicine 2013;19(1):66-72.

PubMed ID

23095468

DOI Link

10.1097/MCP.0b013e32835a5bc8

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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