Document Type

Contribution to Book

Publication Date

8-2015

Keywords

Cystic fibrosis, cystic fibrosis transmembrane conductance regulator, neutrophil function

Funder/Sponsor

U.S. Cystic Fibrosis Foundation and Science Foundation Ireland under the Research Frontiers Programme (11/RFP/BMT/3094) and the Program for Research in Third Level Institutes administered by the Higher Education Authority in Ireland

Comments

This chapter is available from InTech at http://www.intechopen.com/books

Abstract

Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.

Disciplines

Medicine and Health Sciences

Citation

White MM, Gargoum F, Browne N, Hurley K, McElvaney NG and Reeves EP. New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity. In: Wat D (ed) Cystic Fibrosis in the Light of New Research. Rijeka, Croatia: InTech; 2015. p249-278

DOI Link

dx.doi.org/10.5772/60645

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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