Peer Reviewed

1

Document Type

Article

Publication Date

2015

Keywords

Cystic fibrosis, endoplasmic reticulum stress, in vivo study, inflammation, innate immunity, ion conductance, lung disease, nonhuman, pathogenesis, pathophysiology, pneumonia, primary cell culture, priority journal, protein defect, protein expression, Review, RNA processing

Comments

The original article is available at http://www.hindawi.com/

Abstract

The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. These small noncoding RNAs act posttranscriptionally to inhibit protein production. Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.

Disciplines

Medicine and Health Sciences

Citation

McKiernan PJ, Greene CM. MicroRNA Dysregulation in Cystic Fibrosis. Mediators of Inflammation. 2015;2015:529642.

PubMed ID

26185362

DOI Link

10.1155/2015/529642

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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