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Submissions from 2016

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High-throughput profiling for discovery of non-coding RNA biomarkers of lung disease., Paul J. McKiernan and Catherine M. Greene

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Inhaled hypertonic saline for cystic fibrosis: reviewing the potential evidence for modulation of neutrophil signalling and function., Emer P. Reeves, Cormac McCarthy Dr, Oliver J. McElvaney, Maya Sakthi N. Vijayan, Michelle M. White, Danielle M. Dunlea, Kerstin Pohl, Noreen Lacey, and Noel G. McElvaney

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A protocol for a randomised clinical trial of the effect of providing feedback on inhaler technique and adherence from an electronic device in patients with poorly controlled severe asthma., Imran Sulaiman, Elaine Mac Hale, Martin Holmes, Cian Hughes, Shona D'Arcy, Terrence Taylor, Viliam Rapcan, Frank Doyle, Aoife Breathnach, Jansen Seheult, Desmond Murphy, Eoin Hunt, Stephen J. Lane, Abhilash Sahadevan, Gloria Crispino, Greg Diette, Isabelle Killane, Richard B. Reilly, and Richard Costello

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Epidemiology of diabetes and complications among adults in the Republic of Ireland 1998-2015: a systematic review and meta-analysis., Marsha L. Tracey, Michael Gilmartin, Kate O'Neill, Anthony P. Fitzgerald, Sheena M. McHugh, Claire M. Buckley, Ronan J. Canavan, and Patricia M. Kearney

Submissions from 2015

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Team Objective Structured Bedside Assessment (TOSBA) as formative assessment in undergraduate Obstetrics and Gynaecology: a cohort study., Richard P. Deane, Pauline Joyce, and Deirdre J. Murphy

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Developmental control of CFTR: from bioinformatics to novel therapeutic approaches., Catherine M. Greene and Dominik Hartl

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Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease., Karim Jundi and Catherine M. Greene

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The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis., Oliver J. McElvaney, Niamh O'Reilly, Michelle White, Noreen Lacey, Kerstin Pohl, Tanja Gerlza, David A. Bergin, Hilary Kerr, Cormac McCarthy, M Emmet O'Brien, Tiziana Adage, Andreas J. Kungl, Emer P. Reeves, and Noel G. McElvaney

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The Ability of Secretory Leukocyte Protease Inhibitor to Inhibit Apoptosis in Monocytes Is Independent of Its Antiprotease Activity., Niamh McGarry, Catherine M. Greene, Noel G. McElvaney, Sinéad Weldon, and Clifford C. Taggart

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MicroRNA Dysregulation in Cystic Fibrosis., Paul J. McKiernan and Catherine M. Greene

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The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease., M Emmett O'Brien, Kevin Pennycooke, Tomás P. Carroll, Jonathan Shum, Laura T. Fee, Catherine O'Connor, P Mark Logan, Emer P. Reeves, and Noel G. McElvaney

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miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6., Irene K. Oglesby, Raman Agrawal, Marcus A. Mall, Noel G. McElvaney, and Catherine M. Greene

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miR-17 overexpression in cystic fibrosis airway epithelial cells decreases interleukin-8 production., Irene K. Oglesby, Sebastian F. Vencken, Raman Agrawal, Kevin Gaughan, Kevin Molloy, Gerard Higgins, Paul McNally, Noel G. McElvaney, Marcus A. Mall, and Catherine M. Greene

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Non-coding RNA as lung disease biomarkers., Sebastian F. Vencken, Catherine M. Greene, and Paul J. McKiernan

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miR-CATCH: microRNA capture affinity technology., Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen GJ Smith, and Catherine M. Greene

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New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity, Michelle M. White, Fatma Gargoum, Niall Browne, Killian Hurley, Noel G. McElvaney, and Emer P. Reeves

Submissions from 2014

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Telemedicine in pre-hospital care: a review of telemedicine applications in pre-hospital environment., Ahjoku Amadi-Obi, Pedar Gilligan, Niall Owens, and Cathal O'Donnell

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The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity., David A. Bergin, Emer P. Reeves, Killian Hurley, Rebecca Wolfe, Ramia Jameel, Sean Fitzgerald, and Noel G. McElvaney

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Identification and characterisation of eight novel SERPINA1 null mutations., Ilaria Ferrarotti, Tomás P. Carroll, Stefania Ottaviani, Anna M. Fra, Geraldine O Brien, Kevin Molloy, Luciano Corda, Daniela Medicina, David R. Curran, Noel G. McElvaney, and Maurizio Luisetti

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miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency., Tidi Hassan, Tomás P. Carroll, Patrick G. Buckley, Robert Cummins, Shane J. O'Neill, Noel G. McElvaney, and Catherine M. Greene

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Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis., Tidi M. Hassan, Astrid S. Hassan, Ann Igoe, Mark Logan, Cedric Gunaratnam, Noel G. McElvaney, and Shane J. O'Neill

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Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium., Paul J. McKiernan, Kevin Molloy, Sally A. Cryan, Noel G. McElvaney, and Catherine M. Greene

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Cytokine responses to Staphylococcus aureus bloodstream infection differ between patient cohorts that have different clinical courses of infection., Sinead McNicholas, Alida Talento, Joanne O Gorman, Margaret M. Hannan, Maureen Lynch, Catherine M. Greene, Hilary Humphreys, and Deirdre Fitzgerald-Hughes

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Protein quality control in lung disease: it's all about cloud networking., Silke Meiners and Catherine M. Greene

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Access to In-Patient Stroke Services and Multidisciplinary Team (MDT) Rehabilitation: Current Demands and Capacity., Eanna O'Sullivan, David J. Williams, Julie Shanahan-O'Connell, Karen Kirrane, Deirdre Armitage, Walter Leahy, Emma O'Flaherty, and Frances Horgan

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Investigating the relationship between peak inspiratory flow rate and volume of inhalation from a Diskus™ Inhaler and baseline spirometric parameters: a cross-sectional study, Jansen N. Seheult, Simon Costello, Kee Chun Tee, Tariq Bholah, Hasan Al Bannai, Imran Suliman, and Richard W. Costello

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miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production., Sinéad Weldon, Paul McNally, Danny F. McAuley, Irene K. Oglesby, Christine L. Wohlford-Lenane, Jennifer A. Bartlett, Christopher J. Scott, Noel G. McElvaney, Catherine M. Greene, Paul B. McCray, and Clifford C. Taggart

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Long noncoding RNAs in liver cancer: what we know in 2014., Jun Zhao, Catherine M. Greene, Steven G. Gray, and Matthew W. Lawless

Submissions from 2013

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Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis., David A. Bergin, Killian Hurley, Adwait Mehta, Stephen Cox, Dorothy Ryan, Shane J. O'Neill, Emer P. Reeves, and Noel G. McElvaney

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Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique., Tidi Hassan, Stephen GJ Smith, Kevin Gaughan, Irene K. Oglesby, Shane O'Neill, Noel G. McElvaney, and Catherine M. Greene

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Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease., Emer P. Reeves, Nessa Banville, Dorothy M. Ryan, Niamh O'Reilly, David A. Bergin, Kerstin Pohl, Kevin Molloy, Oliver J. McElvaney, Khalifah Alsaleh, Ahmed Aljorfi, Osama Kandalaft, Eimear O'Flynn, Patrick Geraghty, Shane J. O'Neill, and Noel G. McElvaney

Submissions from 2012

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Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency., Woo Jin Kim, Alice M. Wood, Alan F. Barker, Mark L. Brantly, Edward J. Campbell, Edward Eden, Noel G. McElvaney, Stephen I. Rennard, Robert A. Sandhaus, James M. Stocks, James K. Stoller, Charlie Strange, Gerard Turino, Edwin K Silverman, Robert A Stockley, and Dawn L. Demeo

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A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis., Emer P. Reeves, David A. Bergin, Sean Fitzgerald, Elaine Hayes, Joanne Keenan, Michael Henry, Paula Meleady, Isabel Vega-Carrascal, Michelle A. Murray, Teck Boon Low, Cormac McCarthy, Emmet O'Brien, Martin Clynes, Cedric Gunaratnam, and Noel G. McElvaney

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Metastatic pituitary carcinoma in a patient with acromegaly: a case report., Seamus Sreenan, Elizabeth Sengupta, William Tormey, and Richard Landau

Submissions from 2011

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Measurement of the unfolded protein response (UPR) in monocytes., Tomás P. Carroll, Catherine M. Greene, and Noel G. McElvaney

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The prevalence of alpha-1 antitrypsin deficiency in Ireland., Tomás P. Carroll, Catherine A. O'Connor, Olwen Floyd, Joseph McPartlin, Dermot P. Kelleher, Geraldine O'Brien, Borislav D. Dimitrov, Valerie B. Morris, Clifford C. Taggart, and Noel G. McElvaney

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Pulmonary Inflammation in Cystic Fibrosis: Impact of Innate Immunity and Estrogen, Sanjay H. Chotirmall, Brian J. Harvey, Noel G. McElvaney, and Catherine M. Greene

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In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens., Stephane Desgranges, Florie Le Prieult, Alan Daly, Marian Brennan, Dilip K. Rai, Anusha P. Subasinghage, Chandralal M. Hewage, Sally-Ann Cryan, Catherine M. Greene, Noel G. McElvaney, Timothy P. Smyth, Deirdre Fitzgerald-Hughes, Hilary Humphreys, and Marc Devocelle

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Interns as teachers of medical students: a pilot programme., Ben Dunne, P Smyth, Heidi Furlong, Ana Rakovac-Tisdall, D Murphy, and Seamus Sreenan

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Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung., Teck Boon Low, Catherine M. Greene, Shane J. O'Neill, and Noel G. McElvaney

Submissions from 2010

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Gain of function effects of Z alpha-1 antirypsin, Tomás P. Carroll, Noel G. McElvaney, and Catherine M. Greene

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Candida species in cystic fibrosis: A road less travelled., Sanjay H. Chotirmall, Catherine M. Greene, and Noel G. McElvaney

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TLR3 Sensing of Viral Infection, F Dunlevy, Noel G. McElvaney, and Catherine M. Greene

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Editorial: How Can We Target Pulmonary Inflammation in Cystic Fibrosis?, Catherine M. Greene

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Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response, Catherine M. Greene and Noel G. McElvaney

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Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor, Catherine M. Greene, Hugh Ramsay, Robert J. Wells, Shane J. O'Neill, and Noel G. McElvaney

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Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases., Nicolas Guyot, Gudmundur Bergsson, Marcus W. Butler, Catherine M. Greene, Sinéad Weldon, Efrat Kessler, Rodney L. Levine, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

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Alpha-1 antitrypsin deficiency., Emer Kelly, Catherine M. Greene, Tomás P. Carroll, Noel G. McElvaney, and Shane J. O'Neill

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miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression., Irene K. Oglesby, Isabella Bray, Sanjay H. Chotirmall, Raymond L. Stallings, Shane J. O'Neill, Noel G. McElvaney, and Catherine M. Greene

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MicroRNAs in inflammatory lung disease--master regulators or target practice?, Irene K. Oglesby, Noel G. McElvaney, and Catherine M. Greene

Submissions from 2009

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Male fertility in cystic fibrosis., Sanjay H. Chotirmall, Amandeep K. Mann, Peter Branagan, Cassandra O'Donohoe, Anne M. Lyons, Maura G. Flynn, Cedric Gunaratnam, Shane J. O'Neill, and Noel G. McElvaney

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Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery., Catherine M. Greene and Noel G. McElvaney

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Panton Valentine leukocidin MSSA leading to multi-organ failure., Teck Boon Low, Leonard Harty, Michelle Murray, Charles Andrews, and Shane J. O'Neill

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Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency, Caitriona McLean, Catherine M. Greene, and Noel G. McElvaney

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Predictive validity of measurements of clinical competence using the team objective structured bedside assessment (TOSBA): assessing the clinical competence of final year medical students., Frances M. Meagher, Marcus W. Butler, Stanley DW Miller, Richard Costello, Ronán Conroy, and Noel G. McElvaney

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Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2., Niall T. Stevens, Irina Sadovskaya, Said Jabbouri, Tafiq Sattar, James P. O'Gara, Hilary Humphreys, and Catherine M. Greene

Submissions from 2008

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Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway., David A. Bergin, Catherine M. Greene, Erwin E. Sterchi, Cliona Kenna, Patrick Geraghty, Abderazzaq Belaaouaj, Clifford C. Taggart, Shane J. O'Neill, and Noel G. McElvaney

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Toll-like receptors as therapeutic targets in cystic fibrosis., Catherine M. Greene, Peter Branagan, and Noel G. McElvaney

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Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations., Catherine M. Greene, Stanley DW Miller, Tomás Carroll, Caitriona McLean, Michael O'Mahony, Matthew W. Lawless, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

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Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis., Niall T. Stevens, M Tharmabala, T Dillane, Catherine M. Greene, James P. O'Gara, and Hilary Humphreys

Submissions from 2007

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Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression., Patrick Geraghty, Catherine M. Greene, Michael O'Mahony, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

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Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression., Patrick Geraghty, Mark P. Rogan, Catherine M. Greene, Rachel MM Boxio, Tiphaine Poiriert, Michael O'Mahony, Abderazzaq Belaaouaj, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

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Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke., Ruth E. MacRedmond, Catherine M. Greene, Delbert R. Dorscheid, Noel G. McElvaney, and Shane J. O'Neill

Submissions from 2006

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Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway., Marcus W. Butler, Ian Robertson, Catherine M. Greene, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

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Antimicrobial proteins and polypeptides in pulmonary innate defence., Mark P. Rogan, Patrick Geraghty, Catherine M. Greene, Shane J. O'Neill, Clifford C. Taggart, and Noel G. McElvaney

Submissions from 2005

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Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide., Ruth E. MacRedmond, Catherine M. Greene, Clifford C. Taggart, Noel G. McElvaney, and Shane J. O'Neill

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Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding., Clifford C. Taggart, Sally-Ann Cryan, Sinead Weldon, Aileen Gibbons, Catherine M. Greene, Emer Kelly, Teck Boon Low, Shane J. O'neill, and Noel G. McElvaney