Peer Reviewed

1

Document Type

Article

Publication Date

9-2-2017

Keywords

Genomics, Population Structure, History, Irish Travellers.

Funder/Sponsor

Science Foundation Ireland. Barouh and Channah Berkovits Foundation. Wellcome Trust.

Comments

The original article is available at www.nature.com

Abstract

The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, 'settled' Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, is the extent of population structure within the Irish Travellers, the time of divergence from the general Irish population, or the extent of autozygosity. Using a sample of 50 Irish Travellers, 143 European Roma, 2232 settled Irish, 2039 British and 6255 European or world-wide individuals, we demonstrate evidence for population substructure within the Irish Traveller population, and estimate a time of divergence before the Great Famine of 1845-1852. We quantify the high levels of autozygosity, which are comparable to levels previously described in Orcadian 1(st)/2(nd) cousin offspring, and finally show the Irish Traveller population has no particular genetic links to the European Roma. The levels of autozygosity and distinct Irish origins have implications for disease mapping within Ireland, while the population structure and divergence inform on social history.

Disciplines

Life Sciences

Citation

Gilbert, E. et al. Genomic insights into the population structure and history of the Irish Travellers. Sci. Rep. 7, 42187; doi: 10.1038/srep42187 (2017).

PubMed ID

28181990

DOI Link

10.1038/srep42187

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

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