Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Case-Control Studies, European Continental Ancestry Group, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Hypertension, Metabolism, Inborn Errors, Methylamines, Middle Aged, Mutation, Missense, Oxygenases, Polymorphism, Genetic, Risk Factors
Irish Higher Education Authority
BACKGROUND: The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension.
METHODS: FMO3 genotypes (E158K, V257M, E308G) were determined in 387 healthy subjects with ambulatory systolic and diastolic blood pressure measurements, and in a cardiovascular disease population of 1649 individuals, 691(41.9%) of whom had a history of hypertension requiring drug treatment. Haplotypes were determined and their distribution noted.
RESULTS: There was no statistically significant association found between any of the 4 common haplotypes and daytime systolic blood pressure in the healthy population (p = 0.65). Neither was a statistically significant association found between the 4 common haplotypes and hypertension status among the cardiovascular disease patients (p = 0.80).
CONCLUSION: These results suggest that the variants in the FMO3 gene do not predispose to essential hypertension in this population.
Dolan C, Shields DC, Stanton A, O'Brien E, Lambert DM, O'Brien JK, Treacy EP. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. BMC Medical Genetics. 2005 Dec 2;6:41.