Peer Reviewed

1

Document Type

Article

Publication Date

4-2013

Keywords

Platelets; Arenaviridae; Bunyaviridae; Filoviridae; Flaviviridae; Dengue; Viral hemorrhagic fever; Disseminated intravascular coagulation; Anti-platelet agents; Biodefense

Comments

The original article is available at

http://www.omicsonline.org/2157-2526/2157-2526-S12-003.php?aid=12633

Abstract

Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae are all RNA viruses that can induce a coagulopathy in infected patients. While there is a paucity of information on the cause of this coagulopathy, these viruses all produce a severe thrombocytopenia. Here, we review the literature on viral hemorrhagic fever and discuss the role played by platelets in the coagulopathy. We also discuss the possibility of using anti-platelet agents to moderate the coagulopathy, a strategy that might have a role to play in treating patients infected by these viruses.

Disciplines

Life Sciences

Citation

Cox D, Salvato M, Zapata JC. The Role of Platelets in Viral Hemorrhagic Fevers. Journal of Bioterrorism & Biodefense S12:003. doi: 10.4172/2157-2526.S12-003

DOI Link

10.4172/2157-2526.S12-003

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