Platelets; Arenaviridae; Bunyaviridae; Filoviridae; Flaviviridae; Dengue; Viral hemorrhagic fever; Disseminated intravascular coagulation; Anti-platelet agents; Biodefense
Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae are all RNA viruses that can induce a coagulopathy in infected patients. While there is a paucity of information on the cause of this coagulopathy, these viruses all produce a severe thrombocytopenia. Here, we review the literature on viral hemorrhagic fever and discuss the role played by platelets in the coagulopathy. We also discuss the possibility of using anti-platelet agents to moderate the coagulopathy, a strategy that might have a role to play in treating patients infected by these viruses.
Cox D, Salvato M, Zapata JC. The Role of Platelets in Viral Hemorrhagic Fevers. Journal of Bioterrorism & Biodefense S12:003. doi: 10.4172/2157-2526.S12-003