Peer Reviewed

1

Document Type

Article

Publication Date

2-11-2007

Keywords

Analysis of Variance, Animals, Behavior, Animal, Catechol O-Methyltransferase, Exploratory Behavior, Female, Habituation, Psychophysiologic, Heterozygote, Homozygote, Male, Mice, Mice, Knockout, Motor Activity, Phenotype

Comments

This article is available at http://www.sciencedirect.com/science/journal/01664328.

Abstract

Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.

Disciplines

Life Sciences

Citation

Babovic D, O'Tuathaigh CM, O'Sullivan GJ, Clifford JJ, Tighe O, Croke DT, Karayiorgou M, Gogos JA, Cotter D, Waddington JL. Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behavioural Brain Research 2007;183(2):236-9.

PubMed ID

17707921

DOI Link

10.1016/j.bbr.2007.07.006

Included in

Life Sciences Commons

Share

COinS