Document Type
Article
Publication Date
11-2-2007
Keywords
Analysis of Variance, Animals, Behavior, Animal, Catechol O-Methyltransferase, Exploratory Behavior, Female, Habituation, Psychophysiologic, Heterozygote, Homozygote, Male, Mice, Mice, Knockout, Motor Activity, Phenotype
Abstract
Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.
Disciplines
Life Sciences
Citation
Babovic D, O'Tuathaigh CM, O'Sullivan GJ, Clifford JJ, Tighe O, Croke DT, Karayiorgou M, Gogos JA, Cotter D, Waddington JL. Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behavioural Brain Research 2007;183(2):236-9.
PubMed ID
17707921
DOI Link
10.1016/j.bbr.2007.07.006
Comments
This article is available at http://www.sciencedirect.com/science/journal/01664328.